1198616-10-2

Upstream product

• 1519-39-7 (R)-methyl p-tolyl sulfoxide 
• 126946-52-9 ethyl (3S)-3,4-dihydroxy-3,4-O-isopropylidene-butanoate 

Downstream Products

• 1198616-11-3 (S(R),2R,4S)-4,5-O-isopropylidene-1-(p-tolylsulfinyl)pentane-2,4,5-triol 
• 1220638-44-7 (S(R),2S,4S)-4,5-O-isopropylidene-1-(p-tolylsulfinyl)pentane-2,4,5-triol 

Relevant academic research and scientific papers

Structure elucidation and stereoselective total synthesis of pavettamine, the causal agent of gousiekte

The structure elucidation of a novel natural product pavettamine (1), the causal agent of the plant toxicosis gousiekte, is reported. The structure was defined by analysis of NMR and MS data and the relative configuration followed from the 13C NMR data of the acetonide derivative. The absolute stereochemistry was established by total synthesis from (2S)-malic acid using chiral sulfoxide methodology as (2S,4R,8R,10S)-1,11-diamino-6-aza-undecane-2,4,8,10-tetraol.

NEW COMPOUNDS FOR THE TREATMENT OF CANCER

The invention provides a method of preparing the stereoisomers of 1,11-diamino-6-aza- undecane-2,4,8,10-tetraol.