119873-85-7Relevant academic research and scientific papers
Monocyclic β-lactam inhibitors of human leukocyte elastase
Firestone,Barker,Pisano,Ashe,Dahlgren
, p. 2255 - 2262 (2007/10/02)
Two types of monocyclic azetidinones have been synthesized that were designed to inactivate human leukocyte elastase (HLE) in three steps: first, acylation of active-site serine; second, creation of a powerful new electrophilic center; third, covalent cap
β-Lactams via α,β-Unsaturated Acid Chlorides: Intermediates for Carbapenem Antibiotics
Manhas, M. S.,Ghosh, Malay,Bose, Ajay K.
, p. 575 - 580 (2007/10/02)
Stereocontrolled synthesis of α-vinyl β-lactams and their transformation to convenient intermediates for PS-5, PS-6, asparenomycin, and thienamycin are described.
