1198769-50-4Relevant academic research and scientific papers
COPPER CATALYZED CYCLOADDITION OF ORGANIC AZIDES AND 1-HALOALKYNES
-
Page/Page column 33-34, (2011/02/24)
This invention provides a method for preparing a 1,2,3-triazole compound comprising contacting an organic azide with a 2-substitued-1-haloalkyne, in the presence of a copper catalyst and a copper-coordinating ligand (preferably a tertiary amine) in a liquid reaction medium, thereby forming a 1,4,5-substituted-1,2,3-triazole compound including a halo substituent at the 5-position of the triazole, the organic portion of the organic azide at the 1-position of the triazole, and the substituent of the 1-iodoalkyne at the 4-position of the triazole. A method for preparing 1-iodoalkynes is also provided.
Copper(I)-catalyzed cycloaddition of organic azides and 1-iodoalkynes
Hein, Jason E.,Tripp, Jonathan C.,Krasnova, Larissa B.,Sharpless, K. Barry,Fokin, Valery V.
supporting information; experimental part, p. 8018 - 8021 (2010/01/16)
High fidelity: 1-Iodoalkynes react rapidly and selectively with organic azides in the presence of copper(I) catalysts (see scheme; TTTA=tris((1-tert- butyl-1H-1,2,3-triazolyl)methyl)amine). The reaction is compatible with many functional groups and solven
