1198769-62-8

Basic information

• Product Name: 1-benzyl-5-iodo-4-(thiophen-3-yl)-1H-[1,2,3]triazole
• Synonyms: 1-benzyl-5-iodo-4-(thiophen-3-yl)-1H-[1,2,3]triazole
• CAS NO: 1198769-62-8
• Molecular Weight: 367.213
• Mol File: 1198769-62-8.mol

Chemical Properties

• CAS DataBase Reference: 1-benzyl-5-iodo-4-(thiophen-3-yl)-1H-[1,2,3]triazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl-5-iodo-4-(thiophen-3-yl)-1H-[1,2,3]triazole(1198769-62-8)
• EPA Substance Registry System: 1-benzyl-5-iodo-4-(thiophen-3-yl)-1H-[1,2,3]triazole(1198769-62-8)

Safety Data

• Hazardous Substances Data: 1198769-62-8(Hazardous Substances Data)

Upstream product

• 67237-53-0 3-ethynylthiophene 
• 622-79-7 benzyl azide 
• 1049777-72-1 1-iodo-2-(3-thiophenyl)ethyne 

Downstream Products

• 1428318-60-8 C₁₃H₁₀FN₃S 

Relevant articles and documents

Base-catalyzed hydrogen–deuterium exchange and dehalogenation reactions of 1,2,3-triazole derivatives

An efficient and convenient synthesis of deuterium-labeled 1,2,3-triazoles using base-catalysis with DMSO-d6as the deuterium source was developed. A series of deuterated 1,2,3-triazoles bearing various substituents were produced by hydrogen–deuterium exchange reactions of pre-synthesized original 1,2,3-triazoles, giving high level of deuteration and high yields. The catalytic system was successfully extended to the dehalogenation and halogen–deuterium exchange procedures of iodo-functionalized 1,2,3-triazolyl derivatives. This study forms a promising basis for the future development of 1,2,3-triazolyl-containing organic derivatives, polymeric materials and biomedical molecules.

'Green' synthesis of 1,4-disubstituted 5-iodo-1,2,3-triazoles under neat conditions, and an efficient approach of construction of 1,4,5-trisubstituted 1,2,3-triazoles in one pot

An environmentally friendly and efficient method for synthesis of 1,4-disubstituted 5-iodo-1,2,3-triazoles through [Cu(phen)(PPh3)2]NO3-catalyzed cycloaddition of organic azides and iodoalkynes under solvent-free condition

Halogen exchange (Halex) reaction of 5-iodo-1,2,3-triazoles: Synthesis and applications of 5-fluorotriazoles

A good exchange: 5-Iodo-1,2,3-triazoles undergo facile substitution reactions with fluoride salts, thus providing ready access to 5-fluorotriazoles (see scheme). The latter can be further elaborated with various nucleophiles to furnish fully substituted 1,2,3-triazole compounds. Copyright

COPPER CATALYZED CYCLOADDITION OF ORGANIC AZIDES AND 1-HALOALKYNES

This invention provides a method for preparing a 1,2,3-triazole compound comprising contacting an organic azide with a 2-substitued-1-haloalkyne, in the presence of a copper catalyst and a copper-coordinating ligand (preferably a tertiary amine) in a liquid reaction medium, thereby forming a 1,4,5-substituted-1,2,3-triazole compound including a halo substituent at the 5-position of the triazole, the organic portion of the organic azide at the 1-position of the triazole, and the substituent of the 1-iodoalkyne at the 4-position of the triazole. A method for preparing 1-iodoalkynes is also provided.