119881-02-6

Basic information

• Product Name: Boc-Aminomalonic acid
• Synonyms: Boc-Aminomalonic acid;Propanedioic acid, [[(1,1-dimethylethoxy)carbonyl]amino]- (9CI);2-(tert-butoxycarbonylamino)malonic acid;REF DUPL: Boc-Aminomalonic acid;Boc-AMinoMalonic acid Boc-AMinoMalonic acid
• CAS NO: 119881-02-6
• Molecular Formula: C₈H₁₃NO₆
• Molecular Weight: 219.19192
• Product Categories: N-BOC
• Mol File: 119881-02-6.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 424.0±40.0 °C(Predicted)
• Appearance: /
• Density: 1.348±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• PKA: 2.14±0.34(Predicted)
• CAS DataBase Reference: Boc-Aminomalonic acid(CAS DataBase Reference)
• NIST Chemistry Reference: Boc-Aminomalonic acid(119881-02-6)
• EPA Substance Registry System: Boc-Aminomalonic acid(119881-02-6)

Safety Data

• Hazardous Substances Data: 119881-02-6(Hazardous Substances Data)

Usage

General Description

Boc-Aminomalonic acid is a specialty chemical compound primarily used in medical and scientific research, particularly in the creation of certain types of protective group reagents for amino acids. It is an aminomalonic acid derivative with a Boc (tert-butoxycarbonyl) protective group, which makes it stable and less reactive in various chemical environments, facilitating its use in complex chemical syntheses. Moreover, its unique reactivity and structure make it a valuable asset in the development of different pharmaceuticals. However, like many similar compounds, it must be handled carefully due to potential hazards and toxicity.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 118317-76-3 Boc-Ama(OBn)-OMe 
• 102831-44-7 diethyl tert-butoxycarbonylaminomalonate 

Downstream Products

• 161086-87-9 tert-butyloxycarbonylaminomalonyl-bis-(L-phenylalanine isobutyl ester) 
• 1068-84-4 2-aminomalonic acid 

Relevant articles and documents

Glutathione peroxidase-like activity of amino-substitutedwater-soluble cyclic selenides: A shift of the major catalytic cycle in methanol

We previously reported that water-soluble cyclic selenides can mimic the antioxidative function of glutathione peroxidase (GPx) in water through a simple catalytic cycle, in which the selenide (>Se) is oxidized by H2O2 to the selenoxide (>Se=O) and the selenoxide is reduced by a thiol back to the selenide. In methanol, however, the GPx-like activity could not be explained by this simple scenario. To look into the reasons for the unusual behaviors in methanol, monoamino-substituted cyclic selenides with a variable ring size were synthesized, and the intermediates of the catalytic cycle were characterized by means of 77Se-NMR and LC-MS spectroscopies. In water, it was confirmed that the selenide and the selenoxide mainly contribute to the antioxidative function, though a slight contribution from the dihydroxy selenane (>Se(OH)2) was also suggested. In methanol, on the other hand, other active species, such as hydroxyselenonium (>Se+-OH) and hydroxy perhydroxy selenane (>Se(OH)(OOH)), could be generated to build another catalytic cycle. This over-oxidation would be more feasible for amino-substituted cyclic selenides, probably because the ammonium (NH3 +) group would transfer a proton to the selenoxide moiety to produce a hydroxyselenonium species in the absence of an additional proton source. Thus, a shift of the major catalytic cycle in methanol would make the GPx-like antioxidative function of selenides perplexing.

Amidomalonamides useful as inhibitors of MMP of matrix metalloproteinase

The present application relates to novel aminomalonamides of the formula and pharmaceutical composition thereof which are useful for inhibiting matrix metalloproteinases.

RENIN INHIBITORS IV

The invention concerns novel renin-inhibitory peptides which are useful for treating renin-assocated hypertension, hyperaldosteronism, and congestive heart failure. Processes for preparing the peptides, compositions containing them and methods of using them are included. Also included is a diagnostic method which uses the compounds to determine the presence of renin-associated hypertension or hyperaldosteronism.