1199-33-3

Basic information

• Product Name: 2-Benzothiazolecarboxaldehyde,oxime(7CI,8CI,9CI)
• Synonyms: 2-Benzothiazolecarboxaldehyde,oxime(7CI,8CI,9CI)
• CAS NO: 1199-33-3
• Molecular Formula: C₈H₆N₂OS
• Molecular Weight: 178.21
• Product Categories: BENZOTHIAZOLE
• Mol File: 1199-33-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 259.4°Cat760mmHg
• Flash Point: 110.7°C
• Appearance: /
• Density: 1.42g/cm³
• Vapor Pressure: 0.013mmHg at 25°C
• Refractive Index: 1.711
• CAS DataBase Reference: 2-Benzothiazolecarboxaldehyde,oxime(7CI,8CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Benzothiazolecarboxaldehyde,oxime(7CI,8CI,9CI)(1199-33-3)
• EPA Substance Registry System: 2-Benzothiazolecarboxaldehyde,oxime(7CI,8CI,9CI)(1199-33-3)

Safety Data

• Hazardous Substances Data: 1199-33-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H6N2OS/c11-9-5-8-10-6-3-1-2-4-7(6)12-8/h1-5,10H/b8-5+

Upstream product

• 6639-57-2 benzothiazole-2-carbaldehyde 

Downstream Products

• 93089-98-6 O-Methyl-benzthiazol-2-aldoxim 
• 56313-91-8 Benzthiazol-2-yl-hydroxamsaeurechlorid 
• 42182-65-0 1,3-benzothiazol-2-ylmethanamine 
• 56313-98-5 2-Benzothiazolylnitriloxid 

Relevant articles and documents

Benzothiazole-oxazole type alpha-glucosidase inhibitor and preparation method and application thereof

The invention discloses a benzothiazole-oxazole type alpha-glucosidase inhibitor and a preparation method and application thereof. The method comprises the following steps: adding a compound (II) andhydroxylamine hydrochloride in a methanol aqueous solution and a sodium carbonate aqueous solution to obtain a compound (III); adding the compound (III), zinc powder and ammonium formate in methanol and reacting to obtain a compound (IV); and adding the compound (IV), a compound (V), iodine and potassium carbonate in DMF and reacting to obtain a compound (I). The chemical formula of the compound (I) is as shown in specification, the chemical formula of the compound (II) is as shown in specification, the chemical formula of the compound (III) is as shown in specification, the chemical formula of the compound (IV) is as shown in specification, and the chemical formula of the compound (V) is as shown in specification. The benzothiazole-oxazole type compound has obvious inhibition effect on alpha-glucosidase, the preparation method is simple, reaction conditions are gentle, and thus, the benzothiazole-oxazole type alpha-glucosidase inhibitor is suitable for being industrially produced on alarge scale.

SPIRO-OXADIAZOLINE COMPOUNDS AS AGONISTS OF α-7-NICOTINIC ACETYLCHOLINE RECEPTORS

The present invention relates to novel spiro-oxadiazoline compounds that are suitable as agonists or partial agonists of a7-nAChR, and pharmaceutical compositions of the same, methods of preparing these compounds and compositions, and the use of these compounds and compositions in methods of maintaining, treating and/or improving cognitive function. In particular, methods of administering a spiro-oxadiazoline cx7-nAChR agonist or partial agonist, to a patient in need thereof, for example a patient with a cognitive deficiency and/or a desire to enhance cognitive function, that may derive a benefit therefrom.