1199-49-1

Usage

Uses

Used in Pharmaceutical Industry:
1,2,4-Oxadiazole, 3-(1-methylethyl)-5-(trichloromethyl)is used as a pharmaceutical agent for its antimicrobial, antitumor, and anticonvulsant properties. Its unique structure and functional group allow it to target specific biological pathways, making it a promising candidate for the development of new drugs to treat various diseases.
Used in Pesticide and Herbicide Industry:
1,2,4-Oxadiazole, 3-(1-methylethyl)-5-(trichloromethyl)is also being investigated for its potential use as a pesticide and herbicide. Its chemical properties and ability to target specific organisms make it a candidate for the development of new and effective agricultural chemicals to control pests and weeds.
Research on 1,2,4-Oxadiazole, 3-(1-methylethyl)-5-(trichloromethyl)is ongoing to explore its various potential applications and properties further. Its unique structure and functional group offer opportunities for the development of new drugs and agricultural chemicals, making it a valuable compound for continued study and development.

Upstream product

• 76-02-8 trifluoroacetyl chloride 
• 849833-56-3 N-hydroxyisobutyramidine 
• 4124-31-6 trichloroacetic acid anhydride 

Downstream Products

• 52366-04-8 3-isopropyl-1,2,4-oxadiazol-5-ol 
• 1032823-75-8 ((5-[({1-[3-(1-methylethyl)-1,2,4-oxadiazol-5-yl]-4-piperidinyl}methyl)oxy]-2-[4-(methylsulfonyl)phenyl]pyridine)) 
• 1032824-43-3 2-[((1S)-1-{1-[3-(1-methylethyl)-1,2,4-oxadiazol-5-yl]-4-piperidinyl}ethyl)oxy]-5-[4-(methylsulfonyl)phenyl]pyrazine 
• 1188446-96-9 (4-(3-isopropyl-1,2,4-oxadiazol-5-yloxy)phenyl)methanamine 
• 1188446-94-7 tert-butyl 4-(3-isopropyl-1,2,4-oxadiazol-5-yloxy)benzylcarbamate 
• 1351343-10-6 [(3R,4S)-1-{5-[1-(3-isopropyl-[1,2,4]oxadiazole-5-carbonyl)piperidin-4-ylmethoxy]pyrimidin-2-yl}-4-(2,4,5-trifluoro-phenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

Benzo [d] [1, 3] oxathiol, benzo [d] [1, 3] benzo [d] [1, 3] oxathiol 3 - oxide or 3, 3 - dioxide compounds and G protein-coupled receptor 119 oxathiol action of number as method/use

There are provided compounds containing benzo[d][1,3]oxathiole, benzo[d][1,3]oxathiole 3-oxide, and benzo[d][1,3]oxathiole 3,3-dioxide, as well as uses/methods related thereto, including treatment of diseases and condition associated with GPR119 dysregulation, Type 2 diabetes mellitus, and related metabolic disorders.

COMPOUNDS CONTAINING POLYSUBSTITUTED BENZO[D][1,3]OXATHIOLE, BENZO[D][1,3]OXATHIOLE 3-OXIDE OR BENZO[D][1,3]OXATHIOLE 3,3-DIOXIDE AND METHODS/USES THEREOF AS AGONISTS OF G PROTEIN-COUPLED RECEPTOR 119

There are provided compounds having formula (I), in which: X1 and X2 are selected from certain combinations of O, S, SO and SO2; X3 is selected from CH, CF and N; X4 is selected from CH and N; X6, X6' and X6'' are selected from H, halogen, and certain alkyl, haloalkyl, alkoxy, hydroxyalkyl, and amide groups; X7 and X7' are selected from H, halogen, and certain alkyl, haloalkyl, alkoxy, hydroxyalkyl, aminoalkyl and amide groups, or both X7 and X7' together form a cycloalkyl or heterocycle; and A is selected from certain optionally substituted, alkoxy, piperazinyl and pyrrolidinyl groups. Also provided are compositions comprising these compounds, as well as uses/methods related thereto, including treatment of diseases and conditions associated with GPR119 dysregulation, Type 2 diabetes mellitus, and related metabolic disorders. (I)

OXADIAZOLE COMPOUNDS

The present invention relates to a compound of formula (I) or (II) or a stereoisomer, enantiomer, racemic, or tautomer thereof, (I) (II) wherein R1,R2,R3,L1,L2,L3,L4,L5 and n, have the same meaning as that defined in the claims and the description. The present invention also relates to compositions, in particular pharmaceuticals, comprising such compounds, and to uses of such compounds and compositions for the prevention and/or treatment of metabolic disorders and/or neurodegenerative diseases, and/or protein misfolding disorders.

PROCESS FOR THE PREPARATION OF OXADIAZOLES

Process for the preparation of oxadiazoles, useful as intermediates in the preparation of biologically active molecules.

BICYCLIC COMPOUNDS AND USE AS ANTIDIABETICS

The present invention relates to novel compounds that are useful in the treatment of metabolic disorders, particularly type II diabetes mellitus and related disorders, and also to the methods for the making and use of such compounds.

HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE

The present invention relates to compounds and methods which may be useful as inhibitors of GPR119 for the treatment or prevention of metabolic, cardiovascular, and metabolic diseases.