119932-71-7

Upstream product

• 537041-04-6 (R)-2-[(R)-1-(2,4-Dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-oxo-ethoxy]-3-[(4-methoxy-phenyl)-diphenyl-methoxy]-propionaldehyde 
• 51600-12-5 5'-O-monomethoxytrityluridine 
• 119932-68-2 5'-O-monomethoxytrityl-2',3'-seco-β-D-uridine 
• 18162-48-6 tert-butyldimethylsilyl chloride 

Downstream Products

• 119932-73-9 1-<4(R)-tert-butyldimethylsilyloxymethyl-5-(p-monomethoxytrityloxy)-3-oxa-2(R)-pentyl>uracil 
• 119932-72-8 1-<4(R)-tert-butyldimethylsilyloxymethyl-5-(p-monomethoxytrityloxy)-1-chloro-3-oxa-2(R)-pentyl>uracil 

Relevant academic research and scientific papers

Efficient RNase H-directed cleavage of RNA promoted by antisense DNA or 2′F-ANA constructs containing acyclic nucleotide inserts

The ability of modified antisense oligonucleotides (AONs) containing acyclic interresidue units to support RNase H-promoted cleavage of complementary RNA is described. Manipulation of the backbone and sugar geometries in these conformationally labile mono