119960-01-9

Upstream product

• 1142-20-7 N-Cbz-Ala 
• 38330-80-2 monomethyl monopotassium malonate 

Downstream Products

• 120021-35-4 methyl (3R,4S)-4-(N-benzyloxycarbonylamino)-3-hydroxypentanoate 
• 1586809-85-9 (1'S)-2-[1'-(benzyloxycarbonyl) amino]ethyl-3-methoxycarbonylindole 
• 1586809-86-0 (1'R)-2-[1'-(benzyloxycarbonyl) amino]ethyl-3-methoxycarbonylindole 
• 1586809-88-2 C₁₃H₁₁F₃N₂O₃ 
• 1586809-76-8 C₂₃H₂₇N₃O₃ 
• 1586809-78-0 C₂₀H₂₀N₂O₃ 
• 1586809-77-9 C₁₈H₁₈N₂O₄S 
• 1586809-82-6 (5S)-1-benzyloxycarbonyl-4-hydroxy-5-methyl-3-(2-trifluoroacetamido)phenyl-3-pyrrolin-2-one 
• 141734-37-4 (3R,4S)-4-Benzyloxycarbonylamino-3-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyloxy)-pentanoic acid methyl ester 

Relevant academic research and scientific papers

α-Amino acid derived enaminones and their application in the synthesis of N-protected methyl 5-substituted-4-hydroxypyrrole-3-carboxylates and other heterocycles

A new and simple synthesis of novel N-protected methyl 5-substituted-4- hydroxypyrrole-3-carboxylates, which exist in equilibrium with their 4-oxo tautomers, has been developed in two steps starting from N-protected α-amino acids. The key intermediates ar

A mild titanium-catalyzed synthesis of functionalized amino coumarins as fluorescence labels

In contrast to Bronsted and other Lewis acids ClTi(OiPr)3 is especially suited to catalyze the formation of amino-substituted coumarins from aminophenols and functionalized β-oxo esters in a Pechmann condensation. This straightforward protocol allows the synthesis of fluorescence labels and false fluorescent neurotransmitters.

Synthesis and antitumor activity of novel dolastatin 10 analogs

Dolastatin 10 (1) is a potent antineoplastic pentapeptide. Novel dolastatin 10 analogs each modified at one of the constituent amino acid derivatives, were synthesized and their antitumor activity was evaluated against P388 leukemia in mice. The structural requirements for antitumor activity are discussed. Some of the analogs, 31c, 35c, 38b, and 50c showed excellent activity in vivo. Highly active 50c, which lacks the thiazole group of 1, was selected for further development as an antitumor agent.

Baker's yeast reduction of N-protected methyl 4-amino-3-oxobutanoates and 3-oxopentanoates

Baker's yeast reduction of N-tert-butoxycarbonyl (Boc) or N-benzyloxycarbonyl (Cbz) protected methyl 4-amino-3-oxopentanoates 4b-e and 4-amino-3-oxobutanoates 7a,b stereoselectively afforded the erythro-hydroxy esters 5b-e and (R)-hydroxy esters 8a,b, res