119962-72-0

Usage

Chemical structure

A derivative of hexanoic acid with two tert-butoxycarbonylamino groups attached to carbon atoms at positions 2 and 6.

Function

Commonly used as a protecting group for amino acids in organic synthesis.

Purpose

Protects the amino groups of the molecule from unwanted reactions during synthesis, allowing for selective manipulation of specific functional groups.

Usage

Frequently used in peptide chemistry and pharmaceutical research for precise control over the reactivity of amino acids.

Other applications

Stabilizing agent in pharmaceutical products, and research reagent in biochemistry and cell biology.

Upstream product

• 70-54-2 2,6-diaminocaproic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 70-53-1 2,6-diaminohexanoic acid hydrochloride 

Relevant academic research and scientific papers

Synthesis and characterization of ramose tetralactosyllysyl-chitosan-5- fluorouracil and its in vitro release

In order to improve drug loading and achieve a good release effect, this paper adopts the ramose method, choosing chitosan as the carrier and 5-fluorouracil (5-Fu) as a model drug. Ramose chitosan-lysyl-5-Fu(3) and ramose tetralactosyllysyl- chitosan-5-Fu(6) were synthesized successfully, then the in vitro release of (6) was researched. The results show that the drug loading of (3) and (6) are 9.17 and 1.63% (w/w), respectively. The in vitro release behavior of (6) in pH 7.4 phosphate buffer solution and pH 1.2 HCl-KCl solution were studied. The zero order release time that (6) maintains in alkaline and acidic media are 64 and 24 h, and the total release by 184 h are 71.97 and 82.34%, respectively. The performance is smooth throughout the whole stage of release, and the concentration of cumulative release is lower in the alkaline environment than in the acidic environment over the same time. Springer Science+Business Media B.V. 2012.

Synthesis method for positive charge phospholipid

The invention relates to a synthesis method for positive charge phospholipid. 1,2-Palmitodistearin is adopted as a raw material, and phospholipid DSPE is synthesized; then, lysine is connected to an amino of the DSPE; then, n beta-alanines are connected to two aminos of a BOC-lysine group in the product, finally, a salt is obtained, and a series of positive charge phospholipid is obtained.

1,3-Diarylprop-2-en-1-ones, compositions containing them and use thereof

1,3-Diarylprop-2-en-1-ones and derivatives, compositions containing them, manufacturing process and use. Substituted 1,3-diarylprop-2-en-1-ones with therapeutic activity may be used in oncology.

SYNTHESIS OF POLY(ETHYLENE GLYCOL) BLOCK COPOLYMERS AS POTENTIAL WATER-SOLUBLE DRUG CARRIERS

The synthesis of a model water-soluble drug carrier based on poly(ethylene glycol) (PEG) block copolymers is described.In the copolymers, two blocks of PEG are linked by a biodegradable oligopeptide or amino acid linkage containing the glutamic acid residue. 4-Nitroaniline as a drug model is attached to the γ-carboxyl group of glutamic acid of the polymer carrier via an enzymatically degradable oligopeptide spacer.The oligopeptides used were potential substrates for chymotrypsin.The relationship between the structure of oligopeptides linking two PEG blocks and the rate of chymotrypsin-catalyzed polymer chain degradation as well as the relationship between the structure of the spacer and kinetics of drug model release from the carrier after incubation of chymotrypsin solution is discussed in detail.The results showed that by modifying the structure of oligopeptides in the polymer construct, changes in the rates of both polymer degradation and the drug model release can be achieved in a very broad range.