119973-54-5

Basic information

• Product Name: Carbamic acid, 1-propenyl-, 1,1-dimethylethyl ester, (E)- (9CI)
• Synonyms: Carbamic acid, 1-propenyl-, 1,1-dimethylethyl ester, (E)- (9CI);(E)-tert-butyl prop-1-en-1-ylcarbamate
• CAS NO: 119973-54-5
• Molecular Formula: C₈H₁₅NO₂
• Molecular Weight: 157.2102
• Product Categories: N-BOC
• Mol File: 119973-54-5.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Carbamic acid, 1-propenyl-, 1,1-dimethylethyl ester, (E)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, 1-propenyl-, 1,1-dimethylethyl ester, (E)- (9CI)(119973-54-5)
• EPA Substance Registry System: Carbamic acid, 1-propenyl-, 1,1-dimethylethyl ester, (E)- (9CI)(119973-54-5)

Safety Data

• Hazardous Substances Data: 119973-54-5(Hazardous Substances Data)

Upstream product

• 2592-18-9 N-tert-butoxycarbonyl-L-allo-threonine 
• 78888-18-3 N-tert-butoxycarbonylprop-2-en-1-amine 
• 4248-19-5 tert-butyl carbazate 
• 2592-18-9 Boc-Thr-OH 
• 590-13-6 (Z)-1-propenyl bromide 

Relevant articles and documents

Enantioselective Friedel-Crafts reaction of electron-rich alkenes catalyzed by chiral Bronsted acid

We present the first enantioselective catalysis of the Friedel-Crafts reaction via activation of electron-rich multiple bonds by a chiral Bronsted acid. The reaction of various indole derivatives with a broad range of substituted enecarbamates affords the

Isomerization of N-Allyl Amides to Form Geometrically Defined Di-, Tri-, and Tetrasubstituted Enamides

Enamides represent bioactive pharmacophores in various natural products, and have become increasingly common reagents for asymmetric incorporation of nitrogen functionality. Yet the synthesis of the requisite geometrically defined enamides remains problematic, especially for highly substituted and Z-enamides. Herein we wish to report a general atom economic method for the isomerization of a broad range of N-allyl amides to form Z-di-, tri-, and tetrasubstituted enamides with exceptional geometric selectivity. This report represents the first examples of a catalytic isomerization of N-allyl amides to form nonpropenyl disubstituted, tri- and tetrasubstituted enamides with excellent geometric control. Applications of these geometrically defined enamides toward the synthesis of cis vicinal amino alcohols and tetrasubstituted α-borylamido complexes are discussed.

2,3-DISUBSTITUTED 1 -ACYL-4-AMINO-1,2,3,4-TETRAHYDROQUINOLINE DERIVATIVES AND THEIR USE AS BROMODOMAIN INHIBITORS

The present invention relates to novel compounds of formula (I), wherein R1 is C1-4alkyl; R2 is C1-4alkyl, C3-7cycloalkyl, -CH2CF3, -CH2OCH3 or heterocyclyl; R3 is C1-4alkyl, -CH2F, -CH2OH or -CH2O(O)CH3; R4 when present is as defined in claim 1; R5 when present is H, halo, hydroxy or C1-6alkoxy; A is -NH-, -O-, -S-, -SO-, -SO2-, -N(C1-4alkyl)- or -NC(O)(CH3)-; V is phenyl, heteroaromatic or pyridone any of which may be optionally substituted by 1, 2 or 3 substituents; W is CH or N; X is C or N; Y is C or N; and Z is CH or N; subject to the proviso that no more than 2 of W, X, Y and Z are N, pharmaceutical compositions containing such compounds and to their use as bromodomain inhibitors.