119976-18-0Relevant academic research and scientific papers
Disubstituted aryl compound and application thereof
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Paragraph 0109-0111, (2019/08/06)
The invention relates to bis-substituted aryl compounds and application thereof. The structure of the bis-substituted aryl compounds is disclosed as Formula I, II or III. The experimental verification detects that the bis-substituted aryl compounds can be
Discovery and evaluation of piperid-4-one-containing mono-carbonyl analogs of curcumin as anti-inflammatory agents
Wu, Jianzhang,Zhang, Yali,Cai, Yuepiao,Wang, Jian,Weng, Bixia,Tang, Qinqin,Chen, Xiangjian,Pan, Zheer,Liang, Guang,Yang, Shulin
, p. 3058 - 3065 (2013/07/25)
We previously reported the design and discovery of three series of 5-carbon linker-containing mono-carbonyl analogs of curcumin (MCACs) as excellent anti-inflammatory agents. In continuation of our ongoing research, we designed and synthesized the fourth
Synthesis, cytotoxicity, and structure-activity insight of NH- and N-methyl-3,5-bis-(arylidenyl)-4-piperidones
Gregory, Matthew,Dandavati, Armaan,Lee, Megan,Tzou, Samuel,Savagian, Mia,Brien, Kimberly A.,Satam, Vijay,Patil, Pravin,Lee, Moses
, p. 5588 - 5597 (2013/12/04)
Twenty-one NH- and N-methyl-3,5-bis-(arylidenyl)-4-piperidone analogs of curcumin, 12 of which are novel, were synthesized and evaluated for their cytotoxicity against B16 (murine melanoma) and L1210 (murine lymphoma) cells grown in culture. These curcumi
Lewis acids as mild and effective catalysts for the synthesis of 3,5-bis[(hetero)arylidene]piperidin-4-ones
Leonova, Evgeniya,Makarov, Mihail,Klemenkova, Zinaida,Odinets, Irina
experimental part, p. 1990 - 1999 (2010/12/25)
The aldol-crotonic condensation reactions of N-alkyl- and NH-piperidin-4-one derivatives with (hetero)aromatic aldehydes promoted by Lewis acids or bases were examined. This comparative study has revealed three effective catalytic systems based on Lewis a
Synthesis and spectroscopic and structural studies of cross-conjugated dienones derived from cyclic ketones and aromatic aldehydes
Vatsadze,Manaenkova,Sviridenkova,Zyk,Krut'ko,Churakov,Antipin,Howard,Lang
, p. 1184 - 1194 (2008/02/02)
Cross-conjugated dienones were synthesized by the reactions of cyclic ketones with two equivalents of aromatic aldehydes under basic conditions. An NMR spectroscopic study and X-ray diffraction analysis demonstrated that all reaction products are formed as E,E isomers. Spontaneous photochemical trans-cis isomerization of cross-conjugated dienones under the scattered light in solution was observed for the first time. The degree of isomerization depends mainly on the nature of the central fragment of the dienone molecule. The previously unknown product of photochemical [2+2]-cycloaddition of 2,5-bis[(E)-(3-pyridyl)methylidene]cyclopentanone was synthesized and characterized by spectroscopic methods and X-ray diffraction. Under the conditions used, only one isomer of the cyclobutane adduct was obtained. Springer Science+Business Media, Inc. 2006.
