1199809-29-4

Basic information

• Product Name: (2R,3R,4R,5R)-5-(2-amino-6-(benzyloxy)-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)-4-methyltetrahydrofuran-3-ol
• Synonyms: (2R,3R,4R,5R)-5-(2-amino-6-(benzyloxy)-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)-4-methyltetrahydrofuran-3-ol
• CAS NO: 1199809-29-4
• Molecular Weight: 389.386
• Mol File: 1199809-29-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (2R,3R,4R,5R)-5-(2-amino-6-(benzyloxy)-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)-4-methyltetrahydrofuran-3-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3R,4R,5R)-5-(2-amino-6-(benzyloxy)-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)-4-methyltetrahydrofuran-3-ol(1199809-29-4)
• EPA Substance Registry System: (2R,3R,4R,5R)-5-(2-amino-6-(benzyloxy)-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)-4-methyltetrahydrofuran-3-ol(1199809-29-4)

Safety Data

• Hazardous Substances Data: 1199809-29-4(Hazardous Substances Data)

Usage

General Description

The chemical compound "(2R,3R,4R,5R)-5-(2-amino-6-(benzyloxy)-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)-4-methyltetrahydrofuran-3-ol" is a nucleoside analog that consists of a purine base (2-amino-6-(benzyloxy)-9H-purin-9-yl) linked to a sugar moiety (4-fluoro-2-(hydroxymethyl)-4-methyltetrahydrofuran-3-ol). (2R,3R,4R,5R)-5-(2-amino-6-(benzyloxy)-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)-4-methyltetrahydrofuran-3-ol is often used in the field of medicinal chemistry and drug discovery, as nucleoside analogs have known antiviral and anticancer properties. The specific stereochemistry of this compound, with the (2R,3R,4R,5R) configuration, is important for its biological activity and interaction with cellular enzymes. Additionally, the presence of the 4-fluoro and benzyloxy substituents further modulates its pharmacological profile.

Upstream product

• 874638-80-9 ((2R,3R,4R)-3-benzoyloxy-4-fluoro-4-methyl-5-oxo-tetrahydrofuran-2-yl)methyl benzoate 
• 1199809-22-7 ((2R,3R,4R,5R)-3-(benzoyloxy)-4-fluoro-5-hydroxy-4-methyltetrahydrofuran-2-yl)methyl benzoate 
• 1199809-24-9 (((2R,3R,4R,5R)-3-(benzoyloxy)-5-bromo-4-fluoro-4-methyltetrahydrofuran-2-yl)methyl benzoate) 
• 1199809-26-1 (2R,3R,4R,5R)-5-(2-amino-6-chloro-9H-purin-9-yl)-2-((benzoyloxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl benzoate 
• 100-51-6 benzyl alcohol 

Downstream Products

• 1233335-79-9 (2S)-methyl 2-((((2R,3R,4R,5R)-5-(2-amino-6-(benzyloxy)-9H-purin-9-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorylamino)propanoate 
• 1233343-43-5 (2S)cyclopentyl 2-((((2R,3R,4R,5R) 5-(2-amino-6-(benzyloxy)-9H-purin-9-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorylamino)propanoate 
• 1418141-37-3 C₂₅H₃₆FN₅O₄Si 
• 1418141-18-0 C₂₆H₂₆FN₅O₅ 
• 1418141-36-2 C₃₂H₄₀FN₅O₅Si 
• 1418141-35-1 C₃₈H₄₀FN₅O₆Si 
• 1418141-34-0 C₃₈H₄₂FN₅O₆Si 
• 1418141-33-9 C₄₄H₅₆FN₅O₆Si₂ 
• 1393526-56-1 3′,5′-bis-O-tert-butyldimethylsilyl-2′-deoxy-2′-α-fluoro-2′-β-C-methyl-2-amino-6-benzyloxypurine ribonucleoside 

Relevant articles and documents

The synthesis of hydroxyaminopurine nucleosied (by machine translation)

A compound or salt thereof having the following structure useful for the treatment of hepatitis C virus (HCV): wherein R 7 is C 1-6 alkyl or C 3-6 cycloalkyl and R 8 is -O(C 1-6 alkyl) or -O(C 3-6 cycloalkyl).

NUCLEOSIDE ANALOGS

A purified compound having activity against hepatitis C virus is disclosed.