119993-46-3Relevant academic research and scientific papers
X=Y-ZH SYSTEMS AS POTENTIAL 1,3-DIPOLES. PART 17. SEQUENTIAL MICHAEL ADDITION-5-ENDO-TRIG CYCLISATION OF ARYLIDENE IMINES OF Α-AMINO ACID ESTERS
Grigg, Ronald,Kemp, James,Malone, John F.,Rajviroongit, Shuleewan,Tangthongkum, Anant
, p. 5361 - 5374 (2007/10/02)
Imines of α-amino acid esters undergo regiospecific Michael addition to methyl acrylate or acrylonitrile in good yield in benzene at 25 degC catalysed by benzyltrimethylammonium methoxide (BTAM).The Michael adducts cyclise to a mixture of two stereoisomer
5-Endo-Trig Cyclisation and 1,3-Anionic Cycloaddition in Arylimine Derivatives of α-Amino Acid Esters
Grigg, Ronald,Kemp, James,Malone, John,Tangthongkum, Anant
, p. 648 - 650 (2007/10/02)
Michael adducts of imines of α-amino acid esters are converted into a mixture of two stereoisomeric pyrrolidines by benzyltrimethylammonium methoxide (BTAM) apparently by a 5-endo-trig cyclisation.
