1199944-26-7Relevant academic research and scientific papers
Chromene-triazole-pyrimidine based chemosensor therapeutics for thein vivoandin vitrodetection of Fe3+ions
Shamsiya, Aranhikkal,Bahulayan, Damodaran
supporting information, p. 6760 - 6767 (2021/04/22)
The development of a series of chromene-pyrimidine triad molecules for the selective detection of Fe3+is described. The new chemosensors were synthesized through the sequential use of multicomponent reactions (MCRs) and click chemistry marking its ease and cost effectiveness. The sensor molecules showed turn-off fluorescence towards Fe3+with an extremely low limit of detection (LOI) and a strong affinity to cancer causing CDK2 proteins with binding energy closer to -9.8 kcal mol-1as indicated by the molecular docking studies. The free hydrophilic handles present on the sensors are advantageous for binding with cellular Fe3+demonstrating the potential of these molecules as therapeutics for iron overloading diseases. The therapeutic potential is further illustratedviacytotoxicity studies against the human cervical cancer cell line HeLa, which showed a very low IC50 value of 15 μg mL-1
Synthesis of new polyfunctional 5,6,7,8-tetrahydroimidazo-[1,5-c]pyrimidin- 5-ones by the aza-wittig reaction followed by intramolecular cyclization and 1,3-prototropic shift
Lebed,Kos,Polovinko,Tolmachev,Vovk
experimental part, p. 921 - 927 (2010/01/03)
Ethyl 2-oxo-6-[(triphenyl-λ5-phosphanylidene)aminomethyl] -1,2,3,4-tetrahydropyrimidine-5-carboxylates reacted with organic isocyanates according to the aza-Wittig pattern, and the subsequent intramolecular ring closure and 1,3-H shift resulted
