120-13-8

Basic information

• Product Name: 4-Ethoxy-3-methoxyphenylacetic acid
• Synonyms: RARECHEM AL BO 0342;4-ETHOXY-3-METHOXYPHENYLACETIC ACID;4-Ethoxy-3-methoxybenzeneacetic acid;2-(4-ethoxy-3-methoxyphenyl)acetic acid;2-(4-ethoxy-3-methoxy-phenyl)acetic acid;2-(4-ethoxy-3-methoxy-phenyl)ethanoic acid
• CAS NO: 120-13-8
• Molecular Formula: C₁₁H₁₄O₄
• Molecular Weight: 210.23
• EINECS: 204-372-7
• Product Categories: Aromatic Phenylacetic Acids and Derivatives
• Mol File: 120-13-8.mol
• Article Data: 1

Chemical Properties

• Melting Point: 122-124°C
• Boiling Point: 344.144 °C at 760 mmHg
• Flash Point: 132.005 °C
• Appearance: /
• Density: 1.159 g/cm³
• Vapor Pressure: 2.56E-05mmHg at 25°C
• Refractive Index: 1.522
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.35±0.10(Predicted)
• CAS DataBase Reference: 4-Ethoxy-3-methoxyphenylacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Ethoxy-3-methoxyphenylacetic acid(120-13-8)
• EPA Substance Registry System: 4-Ethoxy-3-methoxyphenylacetic acid(120-13-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 120-13-8(Hazardous Substances Data)

Usage

Chemical Properties

An off-white powder.

Uses

Intermediate.

InChI:InChI=1/C11H14O4/c1-3-15-9-5-4-8(7-11(12)13)6-10(9)14-2/h4-6H,3,7H2,1-2H3,(H,12,13)

Upstream product

• 66488-86-6 (4-ethoxy-3-methoxy-phenyl)-pyruvic acid 
• 18855-52-2 tetraethyl dimethylaminomethylenediphosphonate 
• 120-25-2 4-ethoxy-3-methoxybenzaldehyde 

Downstream Products

• 858843-15-9 (4-ethoxy-5-methoxy-2-nitro-phenyl)-acetic acid 
• 1015484-18-0 C₂₅H₂₆N₆O₃ 
• 872274-89-0 (4-ethoxy-5-methoxy-2-nitro-phenyl)-acetic acid-(3,4-dimethoxy-phenethylamide) 
• 91790-50-0 7-ethoxy-6-methoxy-4-(3,4-dimethoxybenzyl)isochroman-3-one 
• 91790-55-5 7-ethoxy-6-methoxy-4-(3,4-dimethoxybenzylidene)isochroman-3-one 
• 171814-31-6 methyl 6-acetyl-4-ethoxy-3-methoxyphenylacetate 
• 55761-07-4 methyl 4-ethoxy-3-methoxyphenylacetate 

Relevant articles and documents

Electrochemical Oxidation of Aromatic Ethers. Part 9. Proof of the Mode of Aryl-Aryl Coupling in 4-Benzylisochroman-3-ones, and the Oxidative Reactions of 2-and 3-Aralkyl-1,2,3,4-tetrahydroisoquinolines

The influence of the solvent upon the coupling reactions of 4-(3,4-dimethoxybenzyl)-6,7-dimethoxyisochroman-3-one has been studied and it is shown that formation of the product, 7a,8-dihydro-3,10,11-trimethoxy-2H-phenanthrofuran-2,7(5H)-dione, proceeds through a six-membered ring transition state.Anodic oxidation of 2-aralkyl-1,2,3,4-tetrahydroisoquinolines leads to cleavage of the aralkyl substituent, whereas 1,2,3,4-tetrahydro-6,7-dimethoxy-3-(3,4-dimethoxybenzyl)-2-methylisoquinoline cyclises to yield 1,2,3,4-tetrahydro-7,10,11-trimethoxy-3-methyl-2,8a-methanodibenzoazocin-6-one and its 1-hydroxy derivative.