120-29-6

Basic information

• Product Name: Tropine
• Synonyms: TIMTEC-BB SBB006506;N-METHYL-8-AZABICYCLO[3.2.1]OCTAN-3-OL;TROPINE;TROPAN-3ALPHA-OL;TROPANOL;ENDO-8-METHYL-8-AZABICYCLO[3,2.1]OCTAN-3-OL;8-AZA-N-METHYLBICYCLO-[3.2.1]OCTAN-3-OL;3-TROPANOL
• CAS NO: 120-29-6
• Molecular Formula: C₈H₁₅NO
• Molecular Weight: 141.21
• EINECS: 204-384-2
• Product Categories: TROSPIUM CHLORIDE;Alkaloids;Biochemistry;Tropane Alkaloids;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 120-29-6.mol
• Article Data: 20

Chemical Properties

• Melting Point: 50-60 °C(lit.)
• Boiling Point: 233 °C(lit.)
• Flash Point: 232-234°C
• Appearance: White to slightly yellow/Crystalline Powder
• Density: 1.045 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0106mmHg at 25°C
• Refractive Index: 1.4811 (estimate)
• Storage Temp.: 2-8°C
• Solubility: H2O: 0.1 g/mL, clear
• PKA: 3.80(at 15℃)
• Water Solubility: 100 g/L (20 ºC)
• Sensitive: Hygroscopic
• Merck: 14,9781
• BRN: 80188
• CAS DataBase Reference: Tropine(CAS DataBase Reference)
• NIST Chemistry Reference: Tropine(120-29-6)
• EPA Substance Registry System: Tropine(120-29-6)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 26/28-20/22
• Safety Statements: 22-24/25
• RIDADR: 1544
• WGK Germany: 3
• RTECS: YM3875000
• F: 3
• TSCA: Yes
• HazardClass: 6.1(b)
• PackingGroup: III
• Hazardous Substances Data: 120-29-6(Hazardous Substances Data)

Usage

Chemical Properties

white to slightly yellow crystalline powder

Uses

Different sources of media describe the Uses of 120-29-6 differently. You can refer to the following data:
1. Tropine is an oxidative product of Tropane, used to synthesize alkaloid derivatives.
2. Tropine as an oxidative product of Tropane, used to synthesize alkaloid derivatives. Benzatropine and etybenzatropine are derivatives of tropine. It is also a building block of atropine, an anticholinergic drug prototypical of the muscarinic antagonist class.

Definition

ChEBI: A derivative of tropane having a hydroxy group at the 3-position.

Purification Methods

Distil 3-tropanol in steam and crystallise it from Et2O or toluene/pet ether. It sublimes at 60o/0.1mm. Hygroscopic. The hydrochloride has m 280o (from EtOH/Et2O). [Beilstein 21 H 16, 21 I 197, 21 II 17, 21 III/IV 168, 21/1 V 219.]

InChI:InChI=1/C8H15NO/c1-9-6-2-3-7(9)5-8(10)4-6/h6-8,10H,2-5H2,1H3

Synthetic route

formaldehyd (50-00-0) + nortropine (538-09-0) → 3-tropanol (120-29-6)

Conditions	Yield
With sodium tetrahydroborate	95%
With methanol; nickel Hydrogenation;

tropine N-oxide hydrochloride (1234788-77-2) → nortropine (538-09-0) + 3-tropanol (120-29-6)

Conditions	Yield
iron In isopropyl alcohol at 60℃; for 2h; Product distribution / selectivity;	A 84% B 5%
Stage #1: tropine-N-oxide hydrochloride With ferrocene In chloroform for 24h; Reflux; Stage #2: With sodium hydroxide In chloroform; water	A 74% B 8%

tropinone hydrochloride (4827-85-4) → 8,8'-dimethyl-3,3'-dihydroxy-3,3'-bi(8-azabicyclo<3.2.1>octyl) (85089-40-3) + 8-methyl-3-hydroxy-3-(1-hydroxy-1-methylethyl)-8-azabicyclo<3.2.1>octane + 3-tropanol (120-29-6) + pseudotropine (135-97-7)

Conditions	Yield
With isopropyl alcohol for 22h; Heating; Irradiation; PRK-2 mercury-quartz lamp;	A 5% B 22% C 46% D 32%

tropinone hydrochloride (4827-85-4) + isopropyl alcohol (67-63-0) → 8,8'-dimethyl-3,3'-dihydroxy-3,3'-bi(8-azabicyclo<3.2.1>octyl) (85089-40-3) + 8-methyl-3-hydroxy-3-(1-hydroxy-1-methylethyl)-8-azabicyclo<3.2.1>octane + 3-tropanol (120-29-6) + pseudotropine (135-97-7)

Conditions	Yield
for 22h; Heating; Irradiation; PRK-2 mercury-quartz lamp;	A 5% B 22% C 46% D 32%

(1R,3R,5S)-3-Hydroxy-8-isopropyl-8-methyl-8-azonia-bicyclo[3.2.1]octane; iodide (93713-44-1) → endo-8-(1-methylethyl)-8-azabicyclo<3.2.1>octan-3-ol (3423-25-4) + 3-tropanol (120-29-6)

Conditions	Yield
With sodium thiophenolate In acetonitrile; butanone Heating;	A 13% B 40%

3-(2′-phenylpropionyloxy)tropane (16052-39-4) → hydratropic acid (492-37-5, 2328-24-7) + 3-tropanol (120-29-6)

Conditions	Yield
in alkal.Loesung;

tropinone (532-24-1) → Tropanol (7432-10-2, 911648-75-4) + 3-tropanol (120-29-6)

Conditions	Yield
weitere Nebenprodukt:Tropan;bei der elektrolytischen Reduktion in schwach saurer Loesung;

tropinone (532-24-1) → 3-tropanol (120-29-6)

Conditions	Yield
elektrolytische Reduktion in alkal.Loesung;
With methanol; nickel under 44130.5 Torr; Hydrogenation;
With 2,3,5-Trimethoxytetrahydrofuran; nickel at 50℃; Hydrogenation.unter 60 at Anfangsdruck;

tropinone (532-24-1) → 3-tropanol (120-29-6) + pseudotropine (135-97-7)

Conditions	Yield
With aluminum isopropoxide; isopropyl alcohol
With sodium tetrahydroborate In ethanol for 1h;	A 91 mg B 519 mg

sodium acetate (127-09-3) + bromotropinol (27809-79-6) + furan-2,3,5(4H)-trione pyridine (1:1) → 3-tropanol (120-29-6)

homatropine hydrobromide (51-56-9) → MANDELIC ACID (611-71-2, 611-72-3, 17199-29-0, 90-64-2) + 3-tropanol (120-29-6)

Conditions	Yield
at 20 - 47℃; Kinetics; in wss.Loesungen vom pH 7 bis pH 12.5.Hydrolysis;

homatropine (87-00-3) → MANDELIC ACID (611-71-2, 611-72-3, 17199-29-0, 90-64-2) + 3-tropanol (120-29-6)

Conditions	Yield
at 20 - 47℃; Kinetics; in wss.Loesungen vom pH 7 bis pH 12.5.Hydrolysis;

atropine (51-55-8) → 3-tropanol (120-29-6)

Conditions	Yield
With potassium hydroxide

atropine (51-55-8) → 2-phenylacrylic acid (492-38-6) + 3-tropanol (120-29-6)

Conditions	Yield
With barium dihydroxide at 100℃;

atropine (51-55-8) → Tropic acid (529-64-6) + 3-tropanol (120-29-6)

Conditions	Yield
With hydrogenchloride

2-Bromo-8-methyl-8-aza-bicyclo[3.2.1]octan-3-one → 3-tropanol (120-29-6)

Conditions	Yield
With K2CO3,H2/Ra Ni 28 In water under 3.3 Torr; for 1.5h;

(1R,3r,5S)-3-tropoyloxytropanium sulfate (55-48-1, 300-40-3, 620-61-1, 1867-24-9, 2472-17-5, 2623-69-0, 14844-27-0, 5908-99-6) → tropinone (532-24-1) + β-Belladonnin (510-25-8, 5878-33-1, 6696-63-5, 23852-32-6) + α-Belladonnin (510-25-8, 5878-33-1, 6696-63-5, 23852-32-6) + 3-tropanol (120-29-6) + pseudotropine (135-97-7) + apoatropine (500-55-0)

Conditions	Yield
In water for 720h; Irradiation; decomposition in aq. solution; stability after storage in glass and polyethylene containers under various conditions (pH-value, temp., oxidative effects, irradiation);

C21H14Br4O5S*2C8H15NO → C21H14Br4O5S*C8H15NO + 3-tropanol (120-29-6)

Conditions	Yield
In dichloromethane at 25℃; Equilibrium constant;

tropinone (532-24-1) → 3-tropanol (120-29-6)

Conditions	Yield
With L-Selectride Reduction;
With hydrogen In methanol; water at 60 - 65℃; under 6000.6 - 7500.75 Torr; for 6h; Inert atmosphere; Autoclave;	192 g

convolamine → 3-tropanol (120-29-6)

Conditions	Yield
With potassium hydroxide

tropinone (532-24-1) + water (7732-18-5) + nickel upon kieselguhr → 3-tropanol (120-29-6)

Conditions	Yield
Hydrogenation;

tropinone (532-24-1) + water (7732-18-5) + nickel upon pumice stone → 3-tropanol (120-29-6)

Conditions	Yield
Hydrogenation;

ethanol (64-17-5) + tropinone (532-24-1) + platinum → 3-tropanol (120-29-6)

Conditions	Yield
unter 10 at.Hydrogenation;
Hydrogenation;

tropinone (532-24-1) + acetic acid (64-19-7) + platinum → 3-tropanol (120-29-6)

Conditions	Yield
Hydrogenation;

tropinone (532-24-1) + water (7732-18-5) + Raney nickel → 3-tropanol (120-29-6)

Conditions	Yield
Hydrogenation;

2-phenyl-acrylic acid tropan-3-yl ester (14054-31-0) + aq. barium hydroxide solution → 2-phenylacrylic acid (492-38-6) + 3-tropanol (120-29-6)

Conditions	Yield
Hydrolysis;

2-phenyl-acrylic acid tropan-3-yl ester (14054-31-0) + ethanol (64-17-5) + KOH-solution → 2-phenylacrylic acid (492-38-6) + 3-tropanol (120-29-6)

Conditions	Yield
Hydrolysis;

Hyoscyamine (101-31-5) + aq. barium hydroxide solution → Tropic acid (529-64-6) + 3-tropanol (120-29-6)

Conditions	Yield
at 60℃;

water (7732-18-5) + Hyoscyamine (101-31-5) → (S)-tropic acid (16202-15-6) + 3-tropanol (120-29-6)

Conditions	Yield
bei laengerem Aufbewahren;
beim Kochen.Hydrolysis;

tropinone (532-24-1) + alkali boratene → 3-tropanol (120-29-6) + pseudotropine (135-97-7)

Conditions	Yield
Product distribution;

3-tropanol (120-29-6) → tropine N-oxide hydrochloride (1234788-77-2)

Conditions	Yield
Stage #1: 3-tropanol With m-CPBA In chloroform at -30 - -20℃; Stage #2: With hydrogenchloride In chloroform; water	99%
With 3-chloro-benzenecarboperoxoic acid In methanol; chloroform at -30 - -20℃;	99%
Stage #1: 3-tropanol With 3-chloro-benzenecarboperoxoic acid In chloroform at -5 - 0℃; Stage #2: With hydrogenchloride In chloroform; water	90%

ethyl bromoacetate (105-36-2) + 3-tropanol (120-29-6) → C12H22NO3(1+)*Br(1-)

Conditions	Yield
In acetone at 60℃; for 120h; Inert atmosphere;	96%

chloroformic acid ethyl ester (541-41-3) + 3-tropanol (120-29-6) → ethyl 3-endo-3-hydroxy-8-azabicyclo[3.3.1]octane-8-carboxylate (30833-12-6)

Conditions	Yield
In chloroform at 20℃; for 7h; Reflux;	95%

1-bromo dodecane (112-29-8) + 3-tropanol (120-29-6) → N-decyltropiunim bromide

Conditions	Yield
In acetone at 60℃; for 120h; Inert atmosphere;	95%

benzyl bromide (100-39-0) + 3-tropanol (120-29-6) → N-benzyltropinium bromide

Conditions	Yield
In acetone at 60℃; for 120h; Inert atmosphere;	95%

1,4-dibromo-butane (110-52-1) + 3-tropanol (120-29-6) → C20H38N2O2(2+)*2Br(1-)

Conditions	Yield
In toluene for 24h; Reflux;	94%

diphenylchloromethane (90-99-3) + 3-tropanol (120-29-6) → benzatropine (86-13-5, 13050-78-7)

Conditions	Yield
at 160℃; for 1h;	93%

ethyl bromide (74-96-4) + 3-tropanol (120-29-6) → C10H20NO(1+)*Br(1-)

Conditions	Yield
In ethyl acetate at 40℃; for 12h;	92.6%

1-dodecylbromide (143-15-7) + 3-tropanol (120-29-6) → N-dodecyltropinium bromide (112555-20-1)

Conditions	Yield
In acetone at 60℃; for 120h; Inert atmosphere;	92%
With acetonitrile

ethyl 2-fluoro-2-(phenylsulfonyl)acetate (20808-13-3) + 3-tropanol (120-29-6) → C14H18FNO3S

Conditions	Yield
Stage #1: 3-tropanol With di-isopropyl azodicarboxylate at 0 - 20℃; for 1h; Schlenk technique; Stage #2: ethyl 2-fluoro-2-(phenylsulfonyl)acetate In N,N-dimethyl-formamide at 50℃; for 3h; regioselective reaction;	91%

benzoyl chloride (98-88-4) + 3-tropanol (120-29-6) → endo-benzoic acid 8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl ester (19145-60-9)

Conditions	Yield
With triethylamine In toluene for 4h; Reflux;	90%
With potassium tert-butylate In tetrahydrofuran at 20℃; for 2h;	54%
With potassium tert-butylate In tetrahydrofuran at 20 - 30℃; for 2.5h;	54%

1-fluoro-1,1-bis(phenylsulfonyl)methane (910650-82-7) + 3-tropanol (120-29-6) → 8-(2-fluoro-2,2-bis(phenylsulfonyl)ethyl)-8-azabicyclo[3.2.1]octan-3-ol

Conditions	Yield
Stage #1: 3-tropanol With di-isopropyl azodicarboxylate at 0 - 20℃; for 1h; Schlenk technique; Stage #2: 1-fluoro-1,1-bis(phenylsulfonyl)methane In N,N-dimethyl-formamide at 50℃; for 3h; regioselective reaction;	90%

propyl bromide (106-94-5) + 3-tropanol (120-29-6) → N-propyltropine bromide

Conditions	Yield
In ethyl acetate at 49.84℃; for 12h;	90%

1-bromo-hexane (111-25-1) + 3-tropanol (120-29-6) → C14H28NO(1+)*Br(1-)

Conditions	Yield
In toluene at 90℃; for 24h;	90%
In acetone at 60℃; for 20h;	79.38%

methacrylic acid methyl ester (80-62-6) + 3-tropanol (120-29-6) → (1R,3r,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl methacrylate

Conditions	Yield
With tetramethylammonium methyl carbonate at 70℃; for 6h; Molecular sieve; Green chemistry;	90%

2,3-diphenylpropionyl chloride (56042-76-3) + 3-tropanol (120-29-6) → (1R,3r,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl 2,3-diphenylpropanoate

Conditions	Yield
In toluene for 2h; Reflux;	90%

acetyl chloride (75-36-5) + 3-tropanol (120-29-6) → 3-endo-8-methyl-8-azabicyclo[3.3.1]octan-3-ol acetate (3423-27-6)

Conditions	Yield
In chloroform Heating;	89%
at 100℃; for 4h;	20%

m-methoxybenzyl chloride (824-98-6) + 3-tropanol (120-29-6) → C16H24NO2(1+)*Cl(1-)

Conditions	Yield
In toluene at 100℃; for 24h;	89%

1-Bromotetradecane (112-71-0) + 3-tropanol (120-29-6) → N-tetradecyltropinium bromide

Conditions	Yield
In acetone at 60℃; for 120h; Inert atmosphere;	89%

1-bromo-butane (109-65-9) + 3-tropanol (120-29-6) → C12H24NO(1+)*Br(1-)

Conditions	Yield
In ethyl acetate at 75℃; for 24h;	88%
In acetonitrile at 80℃; for 16h;	88.32%
In ethanol for 24h; Reflux;

(2R,3S)-3-((tert-butyldimethylsilyl)oxy)-4,4,4-trifluoro-2-phenylbutanoic acid + 3-tropanol (120-29-6) → (1R,3r,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl (2R,3S)-3-((tert-butyldimethylsilyl)oxy)-4,4,4-trifluoro-2-phenylbutanoate

Conditions	Yield
Stage #1: (2R,3S)-3-((tert-butyldimethylsilyl)oxy)-4,4,4-trifluoro-2-phenylbutanoic acid With dmap; 2-methyl-6-nitrobenzoic anhydride; N-ethyl-N,N-diisopropylamine In dichloromethane at 25℃; for 0.166667h; Inert atmosphere; Stage #2: 3-tropanol In dichloromethane at 25 - 40℃; for 20h; Inert atmosphere;	88%

(2R,3S)-3-((tert-butyldimethylsilyl)oxy)-4,4-difluoro-2-phenylbutanoic acid + 3-tropanol (120-29-6) → (1R,3r,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl (2R,3S)-3-((tert-butyldimethylsilyl)oxy)-4,4-difluoro-2-phenylbutanoate

Conditions	Yield
Stage #1: (2R,3S)-3-((tert-butyldimethylsilyl)oxy)-4,4-difluoro-2-phenylbutanoic acid With dmap; 2-methyl-6-nitrobenzoic anhydride; N-ethyl-N,N-diisopropylamine In dichloromethane at 25℃; for 0.166667h; Inert atmosphere; Stage #2: 3-tropanol In dichloromethane at 25℃; for 20h; Inert atmosphere;	88%

3-tropanol (120-29-6) → nortropine (538-09-0)

Conditions	Yield
With DAP(2+)*2BF4(1-); oxygen In acetonitrile at 20℃; Irradiation;	87%
With DAP(2+)*2BF4(1-); oxygen In acetonitrile at 20℃; Product distribution; Irradiation; photochemical N-demethylation of var. tert. amines;	87%
With sodium hydroxide; water; potassium hexacyanoferrate(III)

3-tropanol (120-29-6) + 2,2,2-Trichloroethyl chloroformate (17341-93-4) → endo-3-hydroxy-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid 2,2,2-trichloro-ethyl ester (866615-14-7)

Conditions	Yield
In toluene at 35℃; for 96.1667 - 96.25h;	87%
With potassium carbonate In benzene at 20℃; for 3.5h; Heating / reflux;
With potassium carbonate In benzene at 20℃; for 3.5h; Heating / reflux;
With potassium carbonate In benzene at 20℃; for 3.5h; Heating / reflux;

Benzilic acid imidazolide (15441-11-9) + 3-tropanol (120-29-6) → Bifentrope (3736-36-5)

Conditions	Yield
In acetone for 2h; Heating;	86.8%

methanesulfonyl chloride (124-63-0) + 3-tropanol (120-29-6) → (1R,3R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl-methane sulfonate (35130-97-3)

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃;	85%
With N-ethyl-N,N-diisopropylamine In dichloromethane at -10 - 0℃; for 5h; Inert atmosphere;	81.3%
With chloroform

1-Bromopentane (110-53-2) + 3-tropanol (120-29-6) → C13H26NO(1+)*Br(1-)

Conditions	Yield
In toluene at 80℃; for 24h;	85%

hexadecanyl bromide (112-82-3) + 3-tropanol (120-29-6) → N-hexadecyltropinium bromide

Conditions	Yield
In acetone at 60℃; for 120h; Inert atmosphere;	85%

Upstream product

• 4827-85-4 tropinone hydrochloride 
• 67-63-0 isopropyl alcohol 
• 791531-41-4 2-Bromo-8-methyl-8-aza-bicyclo[3.2.1]octan-3-one 
• 51-55-8 atropine 
• 87-00-3 homatropine 
• 51-56-9 homatropine hydrobromide 
• 127-09-3 sodium acetate 
• 27809-79-6 bromotropinol 
• 532-24-1 tropinone 
• 16052-39-4 3-(2′-phenylpropionyloxy)tropane 
• 5908-99-6 atropine sulfate 
• 542-05-2 acetonedicarboxylic acid 
• 55-48-1 (1R,3r,5S)-3-tropoyloxytropanium sulfate 
• 1234788-77-2 tropine-N-oxide hydrochloride 

Downstream Products

• 107007-94-3 1H-indazole-3-carboxylic acid 8-methyl-8-azabicyclo<3.2.1>oct-3-yl ester 
• 80830-76-8 1,2-bis(3-α-hydroxy-8-azabicyclo<3,2,1>oct-8-yl)ethane 
• 80830-74-6 8-(2-hydroxy-2-phenylpropyl)-3α-hydroxy-8-azabicyclo<3.2.1>octane 
• 3736-36-5 Bifentrope 
• 155058-86-9 2-(4-Chloro-phenylsulfanyl)-butyric acid (1R,3R,5S)-8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl ester 
• 156143-26-9 (+/-)-PG₉ 
• 155058-82-5 2-(4-Chloro-phenylsulfanyl)-propionic acid (1R,3R,5S)-8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl ester 

Related news

Molecular cloning and catalytic characterization of a recombinant Tropine (cas 120-29-6) biosynthetic tropinone reductase from Withania coagulans leaf09/06/2019

Tropinone reductases (TRs) are small proteins belonging to the SDR (short chain dehydrogenase/reductase) family of enzymes. TR-I and TR-II catalyze the conversion of tropinone into tropane alcohols (tropine and pseudotropine, respectively). The steps are intermediary enroute to biosynthesis of t...detailed

Immobilized chiral Tropine (cas 120-29-6) ionic liquid on silica gel as adsorbent for separation of metal ions and racemic amino acids09/05/2019

Tropine-type chiral ionic liquid with proline anion was immobilized on silica gel by chemical modification method for the first time, which was proved by elemental, infrared spectrum and thermogravimetric analysis. Secondly, the performance of this kind of ionic liquid-modified silica gel was in...detailed

Phase behavior of novel functional Tropine (cas 120-29-6) ionic liquids in binary solvent mixture (water + ethanol): A synergistic effect promoting solubility09/04/2019

Phase diagrams for the binary systems ethanol or water + tropine-type ionic liquids including N-benzyl-tropine hexafluorophosphate, N-(3-methoxybenzyl)-tropine hexafluorophosphate, N-(4-nitrobenzyl)-tropine hexafluorophosphate and related ternary systems (ethanol + water + ionic liquid) were mea...detailed

A resolution approach of racemic phenylalanine with aqueous two-phase systems of chiral Tropine (cas 120-29-6) ionic liquids09/01/2019

Aqueous two-phase systems (ATPS) based on tropine type chiral ionic liquids and inorganic salt solution were designed and prepared for the enantiomeric separation of racemic phenylalanine. The phase behavior of IL-based ATPS was comprehensive investigated, and phase equilibrium data were correla...detailed

Relevant articles and documents

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The synthesis and separation of [3-2H]tropine and [3-2H]pseudotropine (Ψ-tropine)

Tropine was reduced using sodium borodeuteride to give a mixture of the epimers [3-2H]tropine and [3-2H]pseudotropine with the latter compound predominating and constituting about 70% of the mixture. Crystallisation of the product from diethyl ether gave crystals of pure [3-2H]pseudotropine and a supernatant solution containing a mixture of the epimers. Acetylation of this mixture using acetyl chloride preferentially acetylated the pseudotropine and the acetylated products were separated from the tropine by flash chromatography to leave a sample of pure [3-2H]tropine.

Spectroscopic investigation and oxidation of the anticholinergic drug atropine sulfate monohydrate by hexacyanoferrate(III) in aqueous alkaline media: A mechanistic approach

The oxidation of the anticholinergic drug atropine sulfate monohydrate by hexacyanoferrate(III) in aqueous alkaline media was investigated spectrophotometrically by monitoring the decrease in absorbance of hexacyanoferrate(III) (HCF(III)). Oxidation products were identied. The oxidation mechanism was proposed from kinetic studies. The reaction constants involved in the dierent steps of the mechanism were calculated. The eects of added products, ionic strength, and dielectric constant of the reaction were investigated. The polymerization test revealed that oxidation occurred with intervention of free radicals. The activation parameters were evaluated. TUeBITAK.