120003-81-8

Basic information

• Product Name: 6-(ChloroMethyl)-4-Methoxy-5-Methyl-nicotinic Acid Methyl Ester
• Synonyms: 6-(ChloroMethyl)-4-Methoxy-5-Methyl-nicotinic Acid Methyl Ester;6-(ChloroMethyl)-4-Methoxy-5-Methyl-3-pyridinecarboxylic Acid Methyl Ester;Methyl 6-(ChloroMethyl)-4-Methoxy-5-Methyl-3-pyridinecarboxylate
• CAS NO: 120003-81-8
• Molecular Formula: C10H12ClNO3
• Molecular Weight: 230
• Product Categories: Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 120003-81-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 343.0±42.0 °C(Predicted)
• Appearance: /
• Density: 1.218±0.06 g/cm3(Predicted)
• Solubility: Chloroform, Dichloromethane, Dimethylformamide
• PKA: 3.23±0.40(Predicted)
• CAS DataBase Reference: 6-(ChloroMethyl)-4-Methoxy-5-Methyl-nicotinic Acid Methyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(ChloroMethyl)-4-Methoxy-5-Methyl-nicotinic Acid Methyl Ester(120003-81-8)
• EPA Substance Registry System: 6-(ChloroMethyl)-4-Methoxy-5-Methyl-nicotinic Acid Methyl Ester(120003-81-8)

Safety Data

• Hazardous Substances Data: 120003-81-8(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Solid

Uses

Omeprazole intermediate.

Upstream product

• 1174028-18-2 5,6-dimethylnicotinic acid methyl ester 
• 1251762-18-1 C₁₀H₁₃NO₄ 

Relevant articles and documents

Preparation method of omeprazole metabolite

The invention discloses a preparation method of an omeprazole metabolite, and belongs to the field of pharmaceutical synthesis. A reaction route is reasonable in design; the operability is high. The preparation method comprises the following steps of reacting to synthesize a target compound with eight steps of firstly enabling 5,6-methyl dimethylnicotinate to be subjected to oxidation through nitrogen, nitrifying, carrying out nitro-substitution, rearranging, chloridizing, butting with 2-mercapto-5-methoxybenzimidazole, carrying out sulfur oxidation, and carrying out hydrolysis, and the like.The whole route of the preparation method is reasonable in design; the post treatment is simple; raw materials are cheap and are easily obtained, and a prepared and obtained target product has the purity which can be up to 99.7 percent or above, can be used for pharmacokinetic study, is used for providing a test sample for the study of a metabolic mechanism of omeprazole, and has important application value.