120008-53-9

Basic information

• Product Name: N-(8-amino-1-carboxyoctyl)-alanyl-proline
• Synonyms: N-(8-amino-1-carboxyoctyl)-alanyl-proline;(S)-2-[[(S)-1-[[(2S)-2-Carboxypyrrolidin-1-yl]carbonyl]ethyl]amino]-9-aminononanoic acid;AB-47;N-[(S)-8-Amino-1-carboxyoctyl]-L-Ala-L-Pro-OH
• CAS NO: 120008-53-9
• Molecular Formula: C17H31 N3 O5
• Molecular Weight: 357.45
• Mol File: 120008-53-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 596.5°Cat760mmHg
• Flash Point: 314.5°C
• Appearance: /
• Density: 1.206g/cm³
• Vapor Pressure: 9.06E-16mmHg at 25°C
• Refractive Index: 1.535
• CAS DataBase Reference: N-(8-amino-1-carboxyoctyl)-alanyl-proline(CAS DataBase Reference)
• NIST Chemistry Reference: N-(8-amino-1-carboxyoctyl)-alanyl-proline(120008-53-9)
• EPA Substance Registry System: N-(8-amino-1-carboxyoctyl)-alanyl-proline(120008-53-9)

Safety Data

• Hazardous Substances Data: 120008-53-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C17H31N3O5/c1-12(15(21)20-11-7-9-14(20)17(24)25)19-13(16(22)23)8-5-3-2-4-6-10-18/h12-14,19H,2-11,18H2,1H3,(H,22,23)(H,24,25)/t12-,13-,14-/m0/s1

Upstream product

• 120008-64-2 N-<1(s)Ethoxycarbonyl-8-phthalimidooctyl>-L-alanyl-L-proline tert-butyl ester 
• 120008-65-3 N-<1(s)-ethoxycarbonyl-8-tert-butoxycarbonylaminooctyl>-L-alanyl-L-proline tert-butylester 
• 99198-40-0 Ethyl 2-bromo-9-phthalimidononanoate 
• 29375-30-2 (S)-alanyl-(S)-proline tert-butyl ester 
• 120008-66-4 N-<8-Amino-1(s)-ethoxycarbonyloctyl>-L-alanyl-L-proline 

Relevant articles and documents

Synthesis and angiotensin converting enzyme inhibitory activity of N-carboxymethyldipeptides with an ω-aminoalkyl group

A series of novel L-alanyl- and L-lysyl-L-proline derivatives having an ω-amino-1-carboxyalkyl group was prepared, and assayed for their inhibitory activity against angiotensin converting enzyme (ACE). The dicarboxylic acids possessing S,S,S configuration showed potent in vitro ACE inhibitory activity with IC50 values of 0.68-1.4 nmol/l. The length of the carbon chain in the ω-aminoalkyl moiety was varied from 6 to 9 investigate the optimal structure for long-acting ACE inhibitors. The most prolonged activity in vivo was observed with N-[8-amino-1(s)-carboxyoctyl]-L-alanyl-L-proline upon i.v. and p.o.