1200113-25-2Relevant academic research and scientific papers
Three step synthesis of single diastereoisomers of the vicinal trifluoro motif
Brunet, Vincent A.,Slawin, Alexandra M. Z.,O'Hagan, David
supporting information; experimental part, (2010/04/22)
A three step route to single diastereoisomers of the vicinal trifluoromethyl motif is described. The route starts from either syn- or anti-α,β-epoxy alcohols and takes a direct approach in that each of the three steps introduces a fluorine atom in a regio- and stereospecific manner. Starting from either the syn- or the anti-α,β-epoxy alcohol, stereospecific reactions generate two separate diastereoisomeric series of this motif. The route is a significant improvement on an earlier six step strategy.
