120017-13-2Relevant academic research and scientific papers
GENERATION AND CARBONYL ADDITION REACTIONS OF Z-DILITHIOHEX-3-ENE-1,5-DIYNE
Danishefsky, Samuel J.,Yamashita, Dennis S.,Mantlo, Nathan B.
, p. 4681 - 4684 (1988)
The reaction of the title dilithio salt with carbonyl compounds leads to products bearing substructures found in recently discovered enediyne antibiotics.The bis condensation product with benzaldehyde undergoes a novel cycloaromatization reaction.
Total synthesis of calicheamicinone: New arrangements for actuation of the reductive cycloaromatization of aglycon congeners
Haseltine, John N.,Cabal, Maria Paz,Mantlo, Nathan B.,Iwasawa, Nobuharu,Yamashita, Dennis S.,Coleman, Robert S.,Danishefsky, Samuel J.,Schulte, Gayle K.
, p. 3850 - 3866 (2007/10/02)
The total synthesis of dl-calicheamicinone (1) has been accomplished. The key elements of the synthesis were (i) an application of the Becker-Adler reaction to reach compound 91, (ii) an application of the concept of in situ protection to deliver lithiate
