1200184-90-2Relevant academic research and scientific papers
Iridium-catalyzed asymmetric ring-opening of oxabenzonorbornadienes with N-substituted piperazine nucleophiles
Yang, Wen,Luo, Renshi,Yang, Dingqiao
, p. 21103 - 21124 (2016/01/25)
Iridium-catalyzed asymmetric ring-opening of oxabenzonorbornadienes with N-substituted piperazines was described. The reaction afforded the corresponding ring-opening products in high yields and moderate enantioselectivities in the presence of 2.5 mol % [Ir(COD)Cl]2 and 5.0 mol % (S)-p-Tol-BINAP. The effects of various chiral bidentate ligands, catalyst loading, solvent, and temperature on the yield and enantioselectivity were also investigated. A plausible mechanism was proposed to account for the formation of the corresponding trans-ring opened products based on the X-ray structure of product 2i.
Iridium-catalyzed asymmetric ring-opening reactions of oxabenzonorbornadienes with amine nucleophiles
Yang, Dingqiao,Long, Yuhua,Zhang, Junfang,Zeng, Heping,Wang, Sanyong,Li, Chunrong
experimental part, p. 3477 - 3480 (2010/10/04)
We have explored a new iridium-catalyzed ring-opening reaction of oxabenzonorbornadienes with a variety of primary aromatic amine or N-substituted piperazine nucleophiles, affording the corresponding products in excellent yields (up to 99%) with moderate enantioselectivity (25-81% ee). The trans configuration of product 2d was confirmed by X-ray crystallography.
Iridium-catalyzed asymmetric ring-opening reactions of oxabicyclic alkenes with secondary amine ucleophiles
Yang, Dingqiao,Hu, Ping,Long, Yuhua,Wu, Yujuan,Zeng, Heping,Wang, Hui,Zuo, Xiongjun
supporting information; experimental part, (2010/04/22)
Iridium-catalyzed asymmetric ring-opening reactions of oxabicyclic alkenes with various aliphatic and aromatic secondary amines are reported for the first time. The reaction gave the corresponding trans-1,2-dihydronaphthalenol derivatives in good yields w
