120020-07-7Relevant academic research and scientific papers
SOLID-LIQUID PHASE TRANSFER CATALYTIC SYNTHESIS OF α-AMINO ACID VIA ALKYLATION AND NUCLEOPHILIC ADDITION OF BENZALDEHYDE IMINES
Yaozhong, Jiang,Changyou, Zhou,Shengde, Wu,Daimo, Chen,Youan, Ma,Guilan, Liu
, p. 5343 - 5354 (2007/10/02)
A short, mild and efficient synthetic route of α-amino acid via alkylation, Michael addition and carbonyl addition as well as cycloaddition of aldimines derived from glycine and alanine esters with benzaldehyde under solid-liquid phase transfer catalytic condition has been studied.The key to solid-liquid phase transfer catalyzed reactions is the selection of a base for the various reactants.The yield is dependent on the base used.The results obtained using KOH, K2CO3 and Na2CO3 are discussed.The kinetics of solid-liquid PTC benzylation has been investigated and we propose a possible mechanism of solid-liquid PTC as an interface auto-catalytic procedure.The details of some syntheses of α-amino acids are presented.
SOLID-LIQUID PHASE TRANSFER CATALYTIC SYNTHESIS (V) MICHAEL ADDITION, CARBONYL ADDITION REACTIONS OF THE ALDIMINES
Shengde, Wu,Changyou, Zhou,Yaozhong, Jiang
, p. 1479 - 1484 (2007/10/02)
Nucleophilic addition of aldimines to the active methylene compounds and aldehyde compounds can be performed in solid-liquid PTC conditions.The reactions are synthetically useful in preparing α-amino acids.
