120040-63-3

Upstream product

• 2635-13-4 1,2-(methylenedioxy)-4-bromobenzene 
• 882-33-7 diphenyldisulfane 
• 17680-04-5 (3,4-methylenedioxy)phenylmagnesium bromide 
• 120040-58-6 Benzo[1,3]dioxol-5-yl-((S)-5-benzyloxy-2,5-dihydro-furan-3-yl)-methanol 
• 104322-42-1 (-)-(2S)-benzyloxy-2,5-dihydrofuran-4-carboxaldehyde 
• 120040-61-1 5--1,2,3-trimethoxybenzene 
• 120040-60-0 (+)-(2S)-2-(Benzyloxy)-2,5-dihydro-4-<3,4-(methylenedioxy)benzoyl>furan 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 

Downstream Products

• 120040-65-5 Benzo[1,3]dioxol-5-yl-[(3S,4S,5R)-5-benzyloxy-4-(3,4,5-trimethoxy-benzyl)-tetrahydro-furan-3-yl]-methanone 
• 23284-23-3 (+)-trans-burseran 

Relevant academic research and scientific papers

General Conjugate-Addition Method for the Synthesis of Enantiomerically Pure Lignans. Total Synthesis of (-)- and (+)-Burseran, (-)-Dehydroxycubebin, (-)-Trichostin, (-)-Cubebin, (-)-5''-Methoxyhinokinin, and (-)-Hinokinin

Conjugate addition of benzylic diphenyldithioacetal anions to enantiomerically pure (-)-(2R)-and (+)-(2S)-(benzyloxy)-2,5-dihydro-4-furan (2 r and 2 s) gave complete lignan skeletons of the dibenzylbutane class.Desulfurization followed by hydrogenolysis and, when appropriate, oxidation gave the title enantiomerically pure > 99 percent ee) lignans 45 - 50 in 24 - 35 percent overall yields from 2 r and 2 s.