1200437-70-2

Basic information

• Product Name: 6-bromo-9-[3-(hydroxymethyl)phenyl]purine
• Synonyms: 6-bromo-9-[3-(hydroxymethyl)phenyl]purine
• CAS NO: 1200437-70-2
• Molecular Weight: 305.134
• Mol File: 1200437-70-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-bromo-9-[3-(hydroxymethyl)phenyl]purine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-bromo-9-[3-(hydroxymethyl)phenyl]purine(1200437-70-2)
• EPA Substance Registry System: 6-bromo-9-[3-(hydroxymethyl)phenyl]purine(1200437-70-2)

Safety Data

• Hazardous Substances Data: 1200437-70-2(Hazardous Substances Data)

Upstream product

• 767-69-1 6-bromopurine 
• 87199-15-3 [3-(hydroxymethyl)phenyl]boronic acid 

Relevant articles and documents

9-Arylpurines as a novel class of enterovirus inhibitors

Here we report on a novel class of enterovirus inhibitors that can be structurally described as 9-arylpurines. These compounds elicit activity against a variety of enteroviruses in the low μM range including Coxsackie virus A16, A21, A24, Coxsackie virus B3, and echovirus 9. Structure-activity relationship (SAR) studies indicate that a chlorine or bromine atomis required at position 6 of the purine ring for antiviral activity. The most selective compounds in this series inhibited Coxsackie virus B3 replication in a dose-dependent manner with EC50 values around 5-8 μM. Notoxicity on different cell lineswas observed at concentrations up to 250 μM. Moreover, no cross-resistance to TBZE-029 and TTP-8307 CVB3 resistant strains was detected.