120060-81-3Relevant articles and documents
Synthesis of novel antiproliferative hybrid bis-(3-indolyl)methane phosphonate derivatives
Maestro, Aitor,Martín-Encinas, Endika,Alonso, Concepción,Martinez de Marigorta, Edorta,Rubiales, Gloria,Vicario, Javier,Palacios, Francisco
, p. 874 - 883 (2018/09/29)
An efficient synthetic methodology for the preparation of phosphorus substituted bis-(3-indolyl)methane through a double nucleophilic addition of indole derivatives to an in situ generated α-iminophosphonate is reported. In addition, bis-(3-indolyl)methane substrates showed in vitro cytotoxicity, inhibiting the growth of carcinoma human tumor cell lines A549 (carcinomic human alveolar basal epithelial cell) and SKOV03 (human ovarian carcinoma).
Preparation of dialkyl 1-(Alkylamino)alkylphosphonates, alkyl [1-(Alkylamino)alkyl]phenylphosphinates and [1-(Alkylamino)alkyl] diphenylphosphine oxides via in situ generated iminium ions
Goldeman, Waldemar,Soroka, Miroslaw
experimental part, p. 2437 - 2445 (2010/09/04)
The reaction of trialkyl phosphites, dialkyl phenylphosphonites or alkyl diphenylphosphinites with N-alkylalkanimines in the presence of hydrogen chloride gives dialkyl 1-(alkylamino)alkylphosphonates, alkyl amino)alkyl]phenylphosphinates or [1-(alkylamino)alkyl]diphenylphosphine oxides respectively, via Arbusov-like reaction of iminium salts generated in situ from N-alkylalkanimines. This reaction is an alternative and competitive to known method of preparation based on the addition of H-P compounds to N-alkylalkanimines, because it gives higher yields, no heating is necessary, and the isolation of products is easy. Georg Thieme Verlag Stuttgart · New York.
Application of silicon-phosphorus based reagents in synthesis of aminophosphonates. Part 2: Reactions of N-(Triphenylmethyl)-aldimines with the silylated phosphorus acid esters
Boduszek,Soroka
, p. 1105 - 1111 (2007/10/03)
Reactions of silylated phosphorus acid esters with N-triphenylmethylaldimines (N-tritylaldimines) were investigated. N-Tritylmethaneimine reacts at room temperature with a mixture of P(OMe)3 and Me3SiBr forming the corresponding aminophosphonate derivatives in high yield. Other N-tritylimines are resistant toward the silylated reagents at room temperature, but undergo a similar phosphorylation reaction at elevated temperatures to form the expected aminophosphonic acids.
Synthesis and plant growth regulating activity of new triazolo- and pyrazolopyrimidine derivatives of aminomethyl-, aminoalkyloxymethyl dimethylphosphine oxides and (aminomethane)phosphonic acid esters
Stanoeva, Elena,Varbanov, Sabi,Alexieva, Vera,Sergiev, Iskren,Vasileva, Vesselina,Rashkova, Marieta,Georgieva, Angelina
, p. 117 - 133 (2007/10/03)
New triazolo[4,5-d]pyrimidine and pyrazolo[3,4-d]pyrimidine derivatives of aminomethyl- and aminomethyloxymethyl dimethylphosphine oxides 8-14 as well as of esters of (aminomethane) phosphonic acid 18-20 were synthesized. The structure of the compounds prepared was confirmed by means of elemental analysis, IR, 1H- and 31P{1H}-NMR spectroscopy. Tertiary phosphine oxides 8, 9 and 12 as well as phosphonate 20 showed herbicidal and plant growth regulating activity.
PHOSPHONODIPEPTIDES. SYNTHESIS BY HOBt/DCC METHOD, MASS SPECTRA OF THE PROTECTED AND 1H NMR OF THE UNPROTECTED PHOSPHONODIPEPTIDES
Hermann, Petr,Lukes, Ivan,Maca, Bohumil,Budesinsky, Milos
, p. 43 - 54 (2007/10/02)
Phosphonodipeptides containing aminomethylphosphonic and 1-aminoethylphosphonic acids were synthesized by the active ester method using N-hydroxybenztriazole and DCC.Fragmentation in electron ionization mass spectra (EI/MS) of protected phosphonodipeptide
