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2,3-Pyridinedicarboxylic acid, 5-(trifluoromethyl)-, diethyl ester, also known as TFMDC, is a chemical compound with the molecular formula C13H11F3NO4. It is a diethyl ester of 5-(trifluoromethyl)nicotinic acid and is commonly used in the field of organic synthesis and medicinal chemistry. TFMDC is a colorless to pale yellow liquid with a fruity odor and is typically stored and handled under inert atmosphere or vacuum to prevent degradation. It is considered to be a hazardous substance and should be handled with appropriate safety precautions.

120083-60-5

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120083-60-5 Usage

Uses

Used in Organic Synthesis:
2,3-Pyridinedicarboxylic acid, 5-(trifluoromethyl)-, diethyl ester is used as a building block for the synthesis of various pharmaceuticals, agrochemicals, and other fine chemicals. Its versatile reactivity and pharmacological properties make it a valuable component in the creation of new compounds.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 2,3-Pyridinedicarboxylic acid, 5-(trifluoromethyl)-, diethyl ester is used as a key intermediate in the development of new drugs. Its unique structure and properties contribute to the design and synthesis of potential therapeutic agents.

Check Digit Verification of cas no

The CAS Registry Mumber 120083-60-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,0,0,8 and 3 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 120083-60:
(8*1)+(7*2)+(6*0)+(5*0)+(4*8)+(3*3)+(2*6)+(1*0)=75
75 % 10 = 5
So 120083-60-5 is a valid CAS Registry Number.

120083-60-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name diethyl 5-(trifluoromethyl)pyridine-2,3-dicarboxylate

1.2 Other means of identification

Product number -
Other names diethyl 5-trifluoromethyl-2,3-pyridinedicarboxylate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:120083-60-5 SDS

120083-60-5Downstream Products

120083-60-5Relevant academic research and scientific papers

Selective decarboxylation: A facile synthesis of 3-pyridinecarboxylic acid derivative

Wang, Junhua,Wang, Honglin,Ren, Hongmin,Dong, Lihua

, p. 4139 - 4142 (2009)

A convenient synthesis of 5-trifluoromethyl-3-pyridinecarboxylic acid was developed, involving palladium-catalyzed carbonylation, hydrolysis, and decarboxylation. This novel route features inexpensive starting material and easy operations.

Preparation of dihydropyrrol derivatives as intermediates

-

Page/Page column 4-5, (2009/06/27)

The invention is concerned with a new scalable process for the preparation of compounds of formula I comprising a new process for the preparation of the key intermediate, a dihydropyrrole derivative formula II or a salt thereof.

Synthetic process development and scale up of palladium-catalyzed alkoxycarbonylation of chloropyridines

Crettaz, Roger,Waser, Jerome,Bessard, Yves

, p. 572 - 574 (2013/09/07)

2,3-Dichloropyridines undergo a mono- or a dicarbonylation in the presence of carbon monoxide, an alcohol, and a palladium catalyst, affording selectively either alkyl 3-chloropyridine-2-carboxylates or dialkyl pyridine-2,3-dicarboxylates in good yields, depending on the reaction conditions. For instance, the process could be scaled up for the monoalkoxycarbonylation of 2,3-dichloro-5-(trifluoromethyl)pyridine, affording in high yield and selectivity the corresponding 3-chloro-5-(trifluoromethyl)pyridine-2-carboxylate.

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