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120097-65-6

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120097-65-6 Usage

Description

2-acetamido-4,4,4-trifluorobutanoic acid is a fluorinated chemical compound with the molecular formula C6H8F3NO3. It is characterized by the presence of three fluorine atoms, which confer high chemical stability and durability. The acid functional group endows it with reactivity and polarity, while the acetamido group is capable of engaging in hydrogen bonding and can be a site of bioactivity in pharmaceutical applications. Although its specific uses have not been extensively reported, its unique properties suggest potential applications in synthetic organic chemistry and medicinal chemistry.

Uses

Used in Synthetic Organic Chemistry:
2-acetamido-4,4,4-trifluorobutanoic acid is used as a building block or intermediate for the synthesis of more complex fluorinated organic compounds. Its fluorine content and reactivity make it a valuable component in the development of new materials with enhanced properties.
Used in Medicinal Chemistry:
2-acetamido-4,4,4-trifluorobutanoic acid is used as a potential pharmaceutical precursor or as a component in the design of new drugs. Its hydrogen bonding capability and bioactivity may contribute to the development of therapeutic agents with improved efficacy and selectivity.
Used in Research and Development:
2-acetamido-4,4,4-trifluorobutanoic acid is used as a research compound to study the effects of fluorination on chemical properties and reactivity. Its unique characteristics can provide insights into the design of new molecules with tailored properties for various applications.
It is important to handle 2-acetamido-4,4,4-trifluorobutanoic acid with care in a controlled environment to prevent potential harm or toxic effects due to improper handling.

Check Digit Verification of cas no

The CAS Registry Mumber 120097-65-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,0,0,9 and 7 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 120097-65:
(8*1)+(7*2)+(6*0)+(5*0)+(4*9)+(3*7)+(2*6)+(1*5)=96
96 % 10 = 6
So 120097-65-6 is a valid CAS Registry Number.

120097-65-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Acetamido-4,4,4-trifluorobutanoic acid

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:120097-65-6 SDS

120097-65-6Relevant articles and documents

Helix propensity of highly fluorinated amino acids

Chiu, Hsien-Po,Suzuki, Yuta,Gullickson, Donald,Ahmad, Raheel,Kokona, Bashkim,Fairman, Robert,Cheng, Richard P.

, p. 15556 - 15557 (2006)

Highly fluorinated amino acids have been used to stabilize helical proteins for potential application in various protein-based biotechnologies. To gain further insight into the effect of these highly fluorinated amino acids on helix formation exclusively, we measured the helix propensity of three highly fluorinated amino acids: (S)-5,5,5,5′,5′,5′-hexafluoroleucine (Hfl), (S)-2-amino-4,4,4-trifluorobutyric acid (Atb), and (S)-pentafluorophenylalanine (Pff). We have developed a short chemoenzymatic synthesis of Hfl with extremely high enantioselectivity (>99%). To measure the helix propensity (w) of the amino acids, alanine-based peptides were synthesized, purified, and investigated by circular dichroism spectroscopy (CD). On the basis of the CD data, the helix propensity of hydrocarbon amino acids can decrease up to 24-fold (1.72 kcal·mol-1·residue-1) upon fluorination. This difference in helix propensity has previously been overlooked in estimating the magnitude of the fluoro-stabilization effect (which has been estimated to be 0.32-0.83 kcal·mol-1·residue-1 for Hfl), resulting in a gross underestimation. Therefore, the full potential of the fluoro-stabilization effect should provide even more stable proteins than the fluoro-stabilized proteins to date. Copyright

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