1201187-44-1

Basic information

• Product Name: tert-butyl 5-tosyl-5H-pyrrolo[2,3-b]pyrazin-2-ylcarbamate
• Synonyms: tert-butyl 5-tosyl-5H-pyrrolo[2,3-b]pyrazin-2-ylcarbamate;tert-butyl N-[5-(4-methylbenzenesulfonyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]carbamate
• CAS NO: 1201187-44-1
• Molecular Formula: C₁₈H₂₀N₄O₄S
• Molecular Weight: 388.4408
• Mol File: 1201187-44-1.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• Density: 1.35±0.1 g/cm3(Predicted)
• PKA: 9.45±0.43(Predicted)
• CAS DataBase Reference: tert-butyl 5-tosyl-5H-pyrrolo[2,3-b]pyrazin-2-ylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 5-tosyl-5H-pyrrolo[2,3-b]pyrazin-2-ylcarbamate(1201187-44-1)
• EPA Substance Registry System: tert-butyl 5-tosyl-5H-pyrrolo[2,3-b]pyrazin-2-ylcarbamate(1201187-44-1)

Safety Data

• Hazardous Substances Data: 1201187-44-1(Hazardous Substances Data)

Usage

Uses

tert-Butyl N-[5-(4-methylbenzenesulfonyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]carbamate is a reagent in the synthetic preparation of tricyclic heterocycles and their kinase inhibitory activity. Preparation of novel nitrogen-containing tricyclic compounds as kinase inhibitors for treating immunological and oncological conditions.

Upstream product

• 1201187-46-3 2-amino-5-(p-toluenesulfonyl)-5H-pyrrolo[2,3-b]pyrazine 
• 98-59-9 p-toluenesulfonyl chloride 
• 75-65-0 tert-butyl alcohol 
• 875781-43-4 2-bromo-5H-pyrrolo[2,3-b]pyrazine 
• 1201186-54-0 2-bromo-5-(p-toluenesulfonyl)-5H-pyrrolo[2,3-b]pyrazine 
• 875781-41-2 5-bromo-3-((trimethylsilyl)ethynyl)pyrazine-2-amine 
• 4248-19-5 tert-butyl carbazate 

Downstream Products

• 1201186-08-4 8-cyclohexyl-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazine 
• 1201187-52-1 8-cyclohexyl-3-tosyl-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazine 
• 1421338-21-7 C₂₁H₂₄N₄O₃S 
• 1310726-60-3 (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide 
• 1201187-46-3 2-amino-5-(p-toluenesulfonyl)-5H-pyrrolo[2,3-b]pyrazine 
• 1428243-40-6 (3R,4S)-benzyl 3-(2-(tert-butoxycarbonyl(5-tosyl-5H-pyrrolo[2,3-b]pyrazin-2-yl)amino)acetyl)-4-methylpyrrolidine-1-carboxylate 
• 1428243-46-2 (3S,4R)-N-(2,2-difluoroethyl)-3-methyl-4-(3-tosyl-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)pyrrolidine-1-carboxamide 
• 1428243-47-3 ((3S,4R)-3-methyl-4-(3-tosyl-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)pyrrolidin-1-yl)(morpholino)methanone 
• 1428243-45-1 (3S,4R)-3-methyl-4-(3-tosyl-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)pyrrolidine-1-carbonyl chloride 

Relevant articles and documents

IRAK4 kinase inhibitor and preparation method thereof

The present invention provides a compound represented by a general formula I, and a pharmaceutically acceptable salt, a stereoisomer, an ester, a prodrug, a solvate and a deuterated compound thereof,and the compound is an IRAK4 kinase inhibitor, and can be used for prevention and/or treatment of IRAK4 related diseases, such as autoimmune diseases, inflammatory diseases, cancers, heteroimmune diseases, thromboembolism, atherosclerosis, myocardial infarction and metabolic syndrome.

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