120122-47-6

Basic information

• Product Name: 1-METHYL-4-NITRO-2-(TRICHLOROACETYL)-1H-PYRROLE
• Synonyms: 2,2,2-TRICHLORO-1-(1-METHYL-4-NITRO-1H-PYRROL-2-YL)-ETHANONE;1-METHYL-4-NITRO-2-(TRICHLOROACETYL)-1H-PYRROLE;N-METHYL-4-NITRO-2-TRICHLOROACETYLPYRROLE;2-Trichloro-1-(1-methyl-4-nitro-1H-pyrrol-2-yl)ethanone;2,2,2-Trichloro-1-(1-methyl-4-nitro-1H-pyrrol-2-yl;1-methyl-4-nitro-2-trichloroacetyl pyrrole;2-(Trichloroacetyl)-1-methyl-4-nitropyrrole;4-Nitro-2-(trichloroacetyl)-N-methylpyrrole
• CAS NO: 120122-47-6
• Molecular Formula: C₇H₅Cl₃N₂O₃
• Molecular Weight: 271.49
• Mol File: 120122-47-6.mol
• Article Data: 27

Chemical Properties

• Melting Point: 132-135°C
• Boiling Point: 319.1 °C at 760 mmHg
• Flash Point: 146.8 °C
• Appearance: /
• Density: 1.66
• Vapor Pressure: 0.000345mmHg at 25°C
• Refractive Index: 1.616
• Storage Temp.: -15°C
• PKA: -15.07±0.70(Predicted)
• CAS DataBase Reference: 1-METHYL-4-NITRO-2-(TRICHLOROACETYL)-1H-PYRROLE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-METHYL-4-NITRO-2-(TRICHLOROACETYL)-1H-PYRROLE(120122-47-6)
• EPA Substance Registry System: 1-METHYL-4-NITRO-2-(TRICHLOROACETYL)-1H-PYRROLE(120122-47-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 120122-47-6(Hazardous Substances Data)

Usage

Uses

2,2,2-Trichloro-1-(1-methyl-4-nitro-1H-pyrrol-2-yl)ethanone can be used to develop DNA-binding TEMPO derivative to evaluate nuclear oxidative stress.

InChI:InChI=1/C7H5Cl3N2O3/c1-11-3-4(12(14)15)2-5(11)6(13)7(8,9)10/h2-3H,1H3

Upstream product

• 96-54-8 N-Methylpyrrole 
• 35302-72-8 pyrrol-2-yl trichloromethyl ketone 
• 76-02-8 trifluoroacetyl chloride 
• 21898-65-7 1-methyl-2-trichloroacetyl-1H-pyrrole 

Downstream Products

• 67974-08-7 1-methyl-4-nitro-1H-pyrrole-2-carboxylic acid tert-butyl ester 
• 13138-74-4 methyl 4-nitropyrrole-2-carboxylate 
• 2853-29-4 ethyl 1-methyl-4-nitro-1H-pyrrole-2-carboxylate 
• 195387-29-2 4-[(9-fluorenylmethoxycarbonyl)amino]-1-methyl-2-pyrrole carboxylic acid 
• 3185-95-3 1-methyl-4-nitro-1H-pyrrole-2-carboxylic acid (2-cyanoethyl)amide 

Relevant articles and documents

Design and Synthesis of Novel Thiazole-Containing Cross-Linked Polyamides Related to the Antiviral Antibiotic Distamycin

A family of naturally occurring oligopeptides includes netropsin, distamycin, anthelvencin, kikumycin B, amidinomycin, and norformycin. Netropsin (I) and distamycin (II) express their biological activities by targeting specific sequences of chemical functionalities in the minor groove of DNA. Both netropsin and distamycin can be regarded as polyamide chains in which each α-carbon has been replaced by a five-membered pyrrole ring. The repeat distance in such an augmented polyamide chain is almost the same as the distance from one base pair to the next along the floor of a minor groove within β-DNA. In this paper we report the synthesis of 16-21 cross-linked polyamides containing a thiazole heterocyclic ring bearing the active functionalites NH2, NHCHO, or H. 16 and 17 were synthesized by DCC and HOBt catalyzed reaction of 5 with 14 and 15, while the formylation products 18 and 19 were obtained by coupling the formylated 4-methyl-thiazolated acid 6 with 14 and 15. The deaminated compounds 20 and 21 were obtained by the coupling of 5-trichloroacetyl-4-methylthiazole 7 synthesized from 4-methylthiazole. All the six cross-linked polyamides 16-21 were tested for their DNA gyrase inhibition. The studies have shown these polyamides have better sequence recognition and a greater percentage of inhibition than the corresponding monomers. The compound 17 shows complete inhibition of gyrase at 0.5 μM concentration as compared to the naturally occurring distamycin at 1.0 μM.

Bromoacetophenone-based photonucleases: photoinduced cleavage of DNA by 4'-bromoacetophenone-pyrrolecarboxamide conjugates.

[formula: see text] 4'-Bromoacetophenone derivatives which upon excitation can generate monophenyl radicals capable of hydrogen atom abstraction were investigated as photoinducible DNA cleaving agents. Pyrrolecarboxamide-conjugated 4'-bromoacetophenones were synthesized, and their DNA cleaving activities and sequence selectivities were determined.

Synthesis, anti-mycobacterial activity and DNA sequence-selectivity of a library of biaryl-motifs containing polyamides

The alarming rise of extensively drug-resistant tuberculosis (XDR-TB) strains, compel the development of new molecules with novel modes of action to control this world health emergency. Distamycin analogues containing N-terminal biaryl-motifs 2(1-5)(1-7)

Synthesis of lipid derivatives of pyrrole polyamide and their biological activity

Novel fatty acyl and phospholipid derivatives of pyrrole polyamide were synthesized. Their cytotoxicity against a cancer cell line of MT-4 cells and those infected by human immunodeficiency virus (HIV) was examined. Although no anti-HIV activity was found, their cytotoxicitty against the cancer cells was significantly enhanced by introducing a lipophilic group into the pyrrole polyamide.

Ortho -Fluoroazobenzene derivatives as DNA intercalators for photocontrol of DNA and nucleosome binding by visible light

We report a high-affinity photoswitchable DNA binder, which displays different nucleosome-binding capacities upon visible-light irradiation. Both photochemical and DNA-recognition properties were examined by UV-Vis, HPLC, CD spectroscopy, NMR, FID assays,

DNA BINDING AGENTS WITH A MINOR GROOVE BINDING TAIL

Provided herein are compounds which intercalate into the DNA of a cell and are capable of crossing the blood brain barrier of a formula provided herein. Pharmaceutical compositions of the compounds and methods of treating cancer, for example brain, lung,