1201221-01-3Relevant academic research and scientific papers
Ligand-accelerating low-loading copper-catalyzed effective synthesis of (E)-1,3-enynes by coupling between vinyl halides and alkynes performed in water
Sun, Peng,Yan, Hong,Lu, Linhua,Liu, Defu,Rong, Guangwei,Mao, Jincheng
supporting information, p. 6969 - 6974 (2013/07/26)
The useful conjugated enynes could be easily prepared via low-loading (0.0001 mol %) copper-catalyzed coupling between vinyl halides and terminal alkynes. It is noteworthy that this reaction could be preformed in water without using any co-solvents and the desired 1,3-enynes could be obtained with good yields. In the catalytic reaction, ligand-acceleration effect was markable.
Palladium-free synthesis of conjugated enynes by direct olefination of terminal alkynes using vinyl bromides
Liu, Yunyun,Yang, Jianguo,Bao, Weiliang
experimental part, p. 5317 - 5320 (2010/02/27)
A series of conjugated enynes were successfully synthesized by the direct copper-catalyzed coupling reaction of vinyl bromides and alkynes. The reaction proceeds smoothly in DMF at 110 °C to give the corresponding products in good to excellent yields. The protocol is tolerant to a broad range of functional groups on the substrates. Moreover, the products were furnished as specific E isomers, as the stereochemistry of the vinyl bromides was retained.
