120131-35-3Relevant articles and documents
New conditions for the synthesis of thiophenes via the Knoevenagel/Gewald reaction sequence. Application to the synthesis of a multitargeted kinase inhibitor
Barnes, David M.,Haight, Anthony R.,Hameury, Thomas,McLaughlin, Maureen A.,Mei, Jianzhang,Tedrow, Jason S.,Riva Toma, Joan Dalla
, p. 11311 - 11319 (2006)
Novel conditions have been developed for the preparation of substituted 2-aminothiophenes employing the Knoevenagel condensation followed by the Gewald reaction. The benefits of these conditions are their mildness, and the ease of product isolation. Thus,
Nitriles in Organic Synthesis: Synthesis of Polysubstituted Anilines and Cyclohexenones
Elagamey, Abdel-Ghani Ali
, p. 766 - 768 (2007/10/02)
Crotononitriles (I) react with cinnamonitriles (III) to afford anilines (IV), ylidenes (VI) or cyclohexenones (VIII).The nature of the end products in these reactions depends on the nature of the reactants and the reaction conditions.