120131-35-3

Upstream product

• 121-89-1 3-Nitroacetophenone 
• 109-77-3 malononitrile 

Downstream Products

• 120131-38-6 2-[(E)-3-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-1-(3-nitro-phenyl)-allylidene]-malononitrile 
• 433958-64-6 2-amino-4-(3-aminophenyl)-6-(2-hydroxyphenyl)nicotinonitrile 
• 433958-47-5 2-amino-6-(2-{[tert-butyl(dimethyl)silyl]oxy}-phenyl)-4-(3-nitrophenyl)pyridine-3-carbonitrile 

Relevant academic research and scientific papers

New conditions for the synthesis of thiophenes via the Knoevenagel/Gewald reaction sequence. Application to the synthesis of a multitargeted kinase inhibitor

Novel conditions have been developed for the preparation of substituted 2-aminothiophenes employing the Knoevenagel condensation followed by the Gewald reaction. The benefits of these conditions are their mildness, and the ease of product isolation. Thus,

Synthesis of di- and triamino-1,1':3',1''-terphenyls from arylethylidene- and arylidenemalonodinitriles

A three-step synthesis of several di- or triamino-m-terphenyls 19 - 23 from 3- or 4-nitrobenzylidenemalonodinitriles 1 and 1-[3- or 4-nitro(or amino)phenyl]ethylidenemalonodinitriles 2 is reported. Gewald's method was applied for a one-pot preparation fro

Nitriles in Organic Synthesis: Synthesis of Polysubstituted Anilines and Cyclohexenones

Crotononitriles (I) react with cinnamonitriles (III) to afford anilines (IV), ylidenes (VI) or cyclohexenones (VIII).The nature of the end products in these reactions depends on the nature of the reactants and the reaction conditions.