1201318-85-5Relevant academic research and scientific papers
Synthesis and antiviral evaluation of 4'-C-azidomethyl -β-D- ribofuranosyl purine and pyrimidine nucleosides
Griffon, Jean-Francois,Dumas, Audrey,Storer, Richard,Sommadossi, Jean-Pierre,Gosselin, Gilles
, p. 435 - 449 (2009)
In the search for inhibitors of the replication of RNA viruses, including hepatitis C virus (HCV), the hitherto unknown 4'-C-azidomethyl - D-ribofuranosyl nucleosides of the five naturally occurring nucleic acid bases have been synthesized and their antiviral properties examined. These 4'-C-branched nucleosides were stereospecifically prepared by glycosylation of purine and pyrimidine aglycons with a suitable peracylated 4-C-azidomethyl-D-pentofuranose sugar, followed by removal of the protecting groups. The prepared compounds were tested for their activity against several viruses, but they did not show an antiviral effect.
