1201324-17-5

Basic information

• Product Name: 5-fluoro-2-[1-(4-methoxybenzyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]oxazolo[5,4-b]pyridine
• Synonyms: 5-fluoro-2-[1-(4-methoxybenzyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]oxazolo[5,4-b]pyridine
• CAS NO: 1201324-17-5
• Molecular Weight: 374.374
• Mol File: 1201324-17-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-fluoro-2-[1-(4-methoxybenzyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]oxazolo[5,4-b]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-fluoro-2-[1-(4-methoxybenzyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]oxazolo[5,4-b]pyridine(1201324-17-5)
• EPA Substance Registry System: 5-fluoro-2-[1-(4-methoxybenzyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]oxazolo[5,4-b]pyridine(1201324-17-5)

Safety Data

• Hazardous Substances Data: 1201324-17-5(Hazardous Substances Data)

Upstream product

• 108118-69-0 2,6-difluoropyridin-3-ylamine 
• 2746-25-0 p-Methoxybenzyl bromide 
• 1201324-18-6 C₁₆H₁₃ClN₂O₂ 
• 849067-96-5 1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid methyl ester 
• 1201324-15-3 1-(4-methoxybenzyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid 
• 1294501-86-2 C₂₁H₁₆F₂N₄O₂ 

Relevant articles and documents

Synthesis and evaluation of 5-fluoro-2-aryloxazolo[5,4- b ]pyridines as β-amyloid PET ligands and identification of MK-3328

5-Fluoro-2-aryloxazolo[5,4-b]pyridines were synthesized and investigated as potential 18F containing β-amyloid PET ligands. In competition binding assays using human AD brain homogenates, compounds 14b, 16b, and 17b were identified as having favorable potency versus human β-amyloid plaque and were radiolabeled for further evaluation in in vitro binding and in vivo PET imaging experiments. These studies led to the identification of 17b (MK-3328) as a candidate PET ligand for the clinical assessment of β-amyloid plaque load.