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1201326-81-9

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1201326-81-9 Usage

General Description

Methyl 5-(Methylsulfonyl)pyridine-2-carboxylate is a chemical compound with the molecular formula C8H9NO4S. It is a derivative of pyridine that contains a methylsulfonyl group attached to the 5th position of the pyridine ring and a methyl ester group attached to the 2nd position. Methyl 5-(Methylsulfonyl)pyridine-2-carboxylate is commonly used in organic synthesis and pharmaceutical research as a building block for the synthesis of various biologically active molecules. It has also shown potential as an anti-inflammatory and analgesic agent in preclinical studies. Methyl 5-(Methylsulfonyl)pyridine-2-carboxylate is a white to off-white crystalline powder that is soluble in organic solvents such as methanol and ethanol.

Check Digit Verification of cas no

The CAS Registry Mumber 1201326-81-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,0,1,3,2 and 6 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1201326-81:
(9*1)+(8*2)+(7*0)+(6*1)+(5*3)+(4*2)+(3*6)+(2*8)+(1*1)=89
89 % 10 = 9
So 1201326-81-9 is a valid CAS Registry Number.

1201326-81-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name Methyl 5-(Methylsulfonyl)pyridine-2-carboxylate

1.2 Other means of identification

Product number -
Other names Methyl 5-(methylsulfonyl)picolinate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1201326-81-9 SDS

1201326-81-9Relevant articles and documents

Malononitrile: A versatile d1-synthon for the synthesis of hetero-aromatic carboxylic acid derivatives

Brünjes, Marco,Ford, Mark James,Dietrich, Hansj?rg,Wilson, Kirsty

, p. 1365 - 1370 (2015)

A convenient one-pot synthesis of heteroaromatic carboxylic acid derivatives from malononitrile substituted heteroaromatic compounds, namely pyridines, pyrimidines, and 1,3,5-triazines is described. In this procedure, the oxidation of malononitriles with

Structural basis and SAR for G007-LK, a lead stage 1,2,4-triazole based specific tankyrase 1/2 inhibitor

Voronkov, Andrew,Holsworth, Daniel D.,Waaler, Jo,Wilson, Steven R.,Ekblad, Bie,Perdreau-Dahl, Harmonie,Dinh, Huyen,Drewes, Gerard,Hopf, Carsten,Morth, Jens P.,Krauss, Stefan

, p. 3012 - 3023 (2013/06/04)

Tankyrases 1 and 2 (TNKS1/2) are promising pharmacological biotargets with possible applications for the development of novel anticancer therapeutics. A focused structure-activity relationship study was conducted based on the tankyrase inhibitor JW74 (1). Chemical analoging of 1 improved the 1,2,4-triazole based core and led to 4-{5-[(E)-2-{4-(2-chlorophenyl)-5-[5- (methylsulfonyl)pyridin-2-yl]-4H-1,2,4-triazol-3-yl}ethenyl]-1,3, 4-oxadiazol-2-yl}benzonitrile (G007-LK), a potent, "rule of 5" compliant and a metabolically stable TNKS1/2 inhibitor. G007-LK (66) displayed high selectivity toward tankyrases 1 and 2 with biochemical IC50 values of 46 nM and 25 nM, respectively, and a cellular IC50 value of 50 nM combined with an excellent pharmacokinetic profile in mice. The PARP domain of TNKS2 was cocrystallized with 66, and the X-ray structure was determined at 2.8 ? resolution in the space group P3221. The structure revealed that 66 binds to unique structural features in the extended adenosine binding pocket which forms the structural basis for the compound's high target selectivity and specificity. Our study provides a significantly optimized compound for targeting TNKS1/2 in vitro and in vivo.

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