1201329-79-4Relevant academic research and scientific papers
Syntheses and antimicrobial activity of tetrasubstituted tetrahydrofuran lignan stereoisomers
Nakato, Tomofumi,Yamauchi, Satoshi,Tago, Ryosuke,Akiyama, Koichi,Maruyama, Masafumi,Sugahara, Takuya,Kishida, Taro,Koba, Yojiro
experimental part, p. 1608 - 1617 (2010/03/01)
The syntheses of all stereoisomers of tetrasubstituted tetrahydrofuran lignan were accomplished, and the antimicrobial activity was examined. The 9, 9′-diol compound bearing (7R, 7′R, 8R, 8′R) and (7R, 7′S, 8R, 8′R) stereochemistry showed the strongest antibacterial activity against Listeria denitrificans and Bacillus subtilis, respectively. It was also found that ()-virgatusin bearing (7S, 7′R, 8S, 8′S) stereochemistry had strongest antifungal activity.
