1201331-15-8

Upstream product

• 872038-32-9 4,4,5,5-tetramethyl-2-[[4-(trifluoromethoxy)phenyl]methyl]-1,3,2-dioxaborolane 
• 121-43-7 Trimethyl borate 
• 50824-05-0 4-trifluoromethoxybenzyl bromide 

Downstream Products

• 1632070-96-2 4-(4-(trifluoromethoxy)benzyl)benzonitrile 
• 719277-21-1 N-(4-(trifluoromethoxy)benzyl)acetamide 

Relevant academic research and scientific papers

Dual Nickel- and Photoredox-Catalyzed Enantioselective Desymmetrization of Cyclic meso-Anhydrides

The enantioselective desymmetrization of cyclic meso-anhydrides with benzyl trifluoroborates under nickel-photoredox catalysis is described. The reaction tolerates a variety of sterically and electronically different trifluoroborates, as well as structurally unique cyclic anhydrides. The trans isomer of the keto-acid products is also observed at varying levels dependent on the trifluoroborate identity and relative catalyst loading. A mechanism involving decarbonylation and Ni?C bond homolysis of a NiII adduct is proposed. This feature allows access to a trans keto-acid as the major product in high enantioselectivity from a cis meso anhydride.

Oxidative nucleophilic substitution: Transformation of alkylboronic derivatives

An efficient amidation reaction is described in this paper. Potassium alkyltrifluoroborate salts can be transforming to amides from nitriles in the presence of copper acetate and boron trifluoride. An extension of this reaction allowed the formation of amines, ethers, and C-C bond.