1201363-81-6 Usage
General Description
(S)-1-(2,5-Difluorophenyl)ethanaMine hydrochloride is a chemical compound with the molecular formula C8H10F2N?HCl. It is a salt form of the chiral amine, and it is commonly used as an intermediate in organic synthesis. (S)-1-(2,5-Difluorophenyl)ethanaMine hydrochloride is a white to off-white crystalline powder that is soluble in water, and it is often utilized in the pharmaceutical industry for the preparation of various drugs. It is also used as a building block for the synthesis of other organic compounds and can be used to create new molecules with specific properties. This chemical is handled and stored in a controlled environment, as it is sensitive to light, air, and moisture, and can degrade if not properly maintained.
Check Digit Verification of cas no
The CAS Registry Mumber 1201363-81-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,0,1,3,6 and 3 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1201363-81:
(9*1)+(8*2)+(7*0)+(6*1)+(5*3)+(4*6)+(3*3)+(2*8)+(1*1)=96
96 % 10 = 6
So 1201363-81-6 is a valid CAS Registry Number.
1201363-81-6Relevant articles and documents
Pyrazolo[1,5-a]pyrimidine based Trk inhibitors: Design, synthesis, biological activity evaluation
Zhang, Yongjie,Liu, Yan,Zhou, Ying,Zhang, Qing,Han, Tianfu,Tang, Chunlei,Fan, Weizheng
, (2021)
Tropomyosin receptor kinases (Trks), a transmembrane receptor tyrosine kinases, have attracted more and more attention as a drug target. Here we reported the structure-based synthesis and biological evaluation of novel pyrazolo[1,5-a]pyrimidine derivatives as Trk inhibitors, which exhibited potent Trk inhibitory activities. Particularly, compounds 8a, 8f, 9a, 9b and 9f (IC50 5 nM) showed significant inhibitory potency against Trk.
Substituted pyrazolo [1,] pyrimidine compounds as Trk inhibitors of formula (I-a)
-
, (2021/10/30)
The present invention relates to a compound having general formula (I) or a pharmaceutically acceptable salt thereof. Use of a pharmaceutical composition and. The pyrazolo [1, 5-I] pyrimidine derivatives having the general formula (a) are synthesized more conveniently and have good Trk family protein tyrosine kinase inhibitory activity.
