120143-22-8

Basic information

• Product Name: 1,2-DI-O-ACETYL-3-AZIDO-3-DEOXY-5-O-TOLUOYL-D-RIBOFURANOSE
• Synonyms: 1,2-DI-O-ACETYL-3-AZIDO-3-DEOXY-5-O-TOLUOYL-D-RIBOFURANOSE;1,2-Di-O-acetyl-3-azido-3-deoxy-5-O-(p-toluoyl)-D-ribofuranose ;1,2-Di-O-acetyl-3-azido-3-deoxy-5-O-(4-methyl)benzoyl-D-ribofuranose;1,2-Di-O-acetyl-3-azido-3-deoxy-5-O-(4-methyl) benzoyl-L-ribofuranose
• CAS NO: 120143-22-8
• Molecular Formula: C₁₇H₁₉N₃O₇
• Molecular Weight: 377.351
• Mol File: 120143-22-8.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• BRN: 7317070
• CAS DataBase Reference: 1,2-DI-O-ACETYL-3-AZIDO-3-DEOXY-5-O-TOLUOYL-D-RIBOFURANOSE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-DI-O-ACETYL-3-AZIDO-3-DEOXY-5-O-TOLUOYL-D-RIBOFURANOSE(120143-22-8)
• EPA Substance Registry System: 1,2-DI-O-ACETYL-3-AZIDO-3-DEOXY-5-O-TOLUOYL-D-RIBOFURANOSE(120143-22-8)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22
• Safety Statements: 36/37
• WGK Germany: 3
• Hazardous Substances Data: 120143-22-8(Hazardous Substances Data)

Usage

Description

1,2-DI-O-ACETYL-3-AZIDO-3-DEOXY-5-O-TOLUOYL-D-RIBOFURANOSE is a complex organic chemical compound with a ribofuranose core structure. It is distinguished by the presence of two acetyl groups, an azido group, and a toluoyl group attached to the ribofuranose ring. 1,2-DI-O-ACETYL-3-AZIDO-3-DEOXY-5-O-TOLUOYL-D-RIBOFURANOSE is primarily utilized in organic synthesis and holds promise for applications in drug development and research of nucleoside analogs. Its intricate molecular structure makes it a valuable asset for studying the reactivity and properties of ribofuranose derivatives, potentially contributing to the design and development of innovative pharmaceutical compounds.

Uses

Used in Organic Synthesis:
1,2-DI-O-ACETYL-3-AZIDO-3-DEOXY-5-O-TOLUOYL-D-RIBOFURANOSE is used as a key intermediate in organic synthesis for the preparation of various complex organic molecules. Its unique functional groups facilitate multiple synthetic pathways, making it a versatile building block in the creation of novel chemical entities.
Used in Drug Development:
In the pharmaceutical industry, 1,2-DI-O-ACETYL-3-AZIDO-3-DEOXY-5-O-TOLUOYL-D-RIBOFURANOSE is used as a precursor in the synthesis of new drug candidates. Its structural features can be exploited to design molecules with specific biological activities, targeting a range of therapeutic areas.
Used in Nucleoside Analogs Research:
1,2-DI-O-ACETYL-3-AZIDO-3-DEOXY-5-O-TOLUOYL-D-RIBOFURANOSE is employed as a starting material in the research and development of nucleoside analogs. These analogs are crucial in the study of nucleic acid metabolism, antiviral and anticancer drug discovery, and the understanding of fundamental biological processes.
Used in Academic Research:
In academic settings, 1,2-DI-O-ACETYL-3-AZIDO-3-DEOXY-5-O-TOLUOYL-D-RIBOFURANOSE serves as a model compound for studying the reactivity and properties of ribofuranose derivatives. Its complex structure provides insights into the design of new chemical reactions and the exploration of novel synthetic methodologies.

Downstream Products

• 1384456-54-5 3'-azido-5'-O-(tert-butyldiphenylsilyl)-3'-deoxyadenosine 
• 58699-62-0 3'-Azido-3'-deoxyadenosine 
• 256485-54-8 4-Methoxy-benzoic acid (2S,3R,4R,5R)-5-[2,6-bis-(2-phenoxy-acetylamino)-purin-9-yl]-4-(tert-butyl-dimethyl-silanyloxy)-3-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-tetrahydro-furan-2-ylmethyl ester 
• 256485-53-7 N-[9-(3-(tert-butyl-dimethyl-silanyloxy)-5-hydroxymethyl-4-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-tetrahydro-furan-2-yl)-2-(2-phenoxy-acetylamino)-9H-purin-6-yl]-2-phenoxy-acetamide 
• 256485-51-5 4-Methyl-benzoic acid (2S,3R,4R,5R)-4-acetoxy-3-azido-5-[2,6-bis-(2-phenoxy-acetylamino)-purin-9-yl]-tetrahydro-furan-2-ylmethyl ester 

Relevant articles and documents

Synthesis of 3'-amino-3'-deoxyadenosine derivatives as potential drugs for the treatment of malaria

A series of 3'-substituted 3'-amino-3'-deoxyadenosine analogues were synthesized and subsequently tested against the human malaria parasite Plasmodium falciparum in vitro. Several amongst them displayed pronounced antiplasmodial activities.