120143-67-1

Basic information

• Product Name: 6β,11α-Dihydroxyandrost-4-ene-3,17-dione
• CAS NO: 120143-67-1
• Molecular Weight: 318.413
• Mol File: 120143-67-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 6β,11α-Dihydroxyandrost-4-ene-3,17-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 6β,11α-Dihydroxyandrost-4-ene-3,17-dione(120143-67-1)
• EPA Substance Registry System: 6β,11α-Dihydroxyandrost-4-ene-3,17-dione(120143-67-1)

Safety Data

• Hazardous Substances Data: 120143-67-1(Hazardous Substances Data)

Upstream product

• 63-05-8 Androstenedione 

Relevant articles and documents

Biocatalyst mediated production of 6β,11α-dihydroxy derivatives of 4-ene-3-one steroids

Biotransformation of steroids with 4-ene-3-one functionality such as progesterone (I), testosterone (II), 17α-methyltestosterone (III), 4-androstene-3,17-dione (IV) and 19-nortestosterone (V) were studied by using a fungal system belonging to the genera of Mucor (M881). The fungal system efficiently and quantitatively converted these steroids in regio- and stereo-selective manner into corresponding 6β,11α-dihydroxy compounds. Time course experiments suggested that the transformation was initiated by hydroxylation at 6β- or 11α-(10β-hydroxy in case of V) to form monohydroxy derivatives which upon prolonged incubation were converted into corresponding 6β,11α-dihydroxy derivatives. The fermentation studies carried out using 5 L table-top fermentor with substrates (I and II) clearly indicates that 6β,11α-dihydroxy derivatives of steroids with 4-ene-3-one functionality can be produced in large scale by using M881.