1201482-15-6Relevant articles and documents
Syntheses of aminoalcohol-derived macrocycles leading to a small-molecule binder to and inhibitor of Sonic Hedgehog
Peng, Lee F.,Stanton, Benjamin Z.,Maloof, Nicole,Wang, Xiang,Schreiber, Stuart L.
supporting information; experimental part, p. 6319 - 6325 (2010/05/02)
We report the synthesis and biological activity of a library of aminoalcohol-derived macrocycles from which robotnikinin (17), a binder to and inhibitor of Sonic Hedgehog, was derived. Using an asymmetric alkylation to set a key stereocenter and an RCM re