1201574-98-2

Basic information

• Product Name: 3-{benzyl[(2R)-2-chloro-2-phenylethyl]amino}propanenitrile
• Synonyms: 3-{benzyl[(2R)-2-chloro-2-phenylethyl]amino}propanenitrile
• CAS NO: 1201574-98-2
• Molecular Weight: 298.815
• Mol File: 1201574-98-2.mol

Chemical Properties

• CAS DataBase Reference: 3-{benzyl[(2R)-2-chloro-2-phenylethyl]amino}propanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-{benzyl[(2R)-2-chloro-2-phenylethyl]amino}propanenitrile(1201574-98-2)
• EPA Substance Registry System: 3-{benzyl[(2R)-2-chloro-2-phenylethyl]amino}propanenitrile(1201574-98-2)

Safety Data

• Hazardous Substances Data: 1201574-98-2(Hazardous Substances Data)

Upstream product

• 706-03-6 3-(benzylamino)propionitrile 
• 20780-53-4 (R)-Styrene oxide 

Downstream Products

• 1201575-00-9 (3R,4S)-1-benzyl-4-phenylpyrrolidine-3-carboxylate 
• 1201575-02-1 (3S,4S)-1-benzyl-4-phenylpyrrolidine-3-carboxylate 
• 1201574-92-6 (3R,4S)-1-benzyl-4-phenylpyrrolidine-3-carboxylic acid 

Relevant articles and documents

NOVEL METHOD FOR PRODUCING OPTICALLY ACTIVE PYRROLIDINE COMPOUND

[Object] A novel method for producing an optically active pyrrolidine compound, which is useful as a production intermediate of a pharmaceutical, and a production intermediate thereof, is provided. [Means for Solution] According to the production method o

A practical and efficient synthesis of (3R,4S)-1-benzyl-4- phenylpyrrolidine-3- carboxylic acid via an aziridinium ion intermediate

A practical and efficient synthesis of (3R,4S)-1-benzyl4-phenylpyr- rolidine-3-carboxylic acid (1), a key chiral building block for synthesis of biologically active compounds was established by utilizing a stereospecific and regioselective chlorination of in situ generated aziridinium ion, followed by a nitrile anion cyclization. Starting from commercially available (R)-styrene oxide and 3-(benzylamino)propionitrile, the four-step synthesis features a through process without purification of intermediates until isolation of crystalline 1. The robust, chromatography-free and reproducible synthesis of 1 achieved an 84% overall yield from (R)-styrene oxide. This highly efficient process was successfully demonstrated at pilot scale with 17 kg output of 1.