120158-57-8

Basic information

• Product Name: 1,1-diacetoxy-1-(3-methylphenyl)-methane
• Synonyms: 1,1-diacetoxy-1-(3-methylphenyl)-methane
• CAS NO: 120158-57-8
• Molecular Weight: 222.241
• Mol File: 120158-57-8.mol

Chemical Properties

• CAS DataBase Reference: 1,1-diacetoxy-1-(3-methylphenyl)-methane(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1-diacetoxy-1-(3-methylphenyl)-methane(120158-57-8)
• EPA Substance Registry System: 1,1-diacetoxy-1-(3-methylphenyl)-methane(120158-57-8)

Safety Data

• Hazardous Substances Data: 120158-57-8(Hazardous Substances Data)

Upstream product

• 620-23-5 m-tolyl aldehyde 
• 108-24-7 acetic anhydride 

Downstream Products

• 620-23-5 m-tolyl aldehyde 

Relevant articles and documents

Sulfonated rice husk ash (RHA-SO3H): A highly powerful and efficient solid acid catalyst for the chemoselective preparation and deprotection of 1,1-diacetates

Rice husk ash (RHA), as a source of amorphous silica, was treated with chlorosulfonic acid and sulfonated rice husk ash (RHA-SO3H) as a highly powerful solid acid catalyst was obtained and characterized with a variety of techniques including IR, TGA, SEM, XRD, pH analysis, Hammett acidity function and BET method. This solid acid showed excellent catalytic activity for the protection and deprotection of aldehydes with Ac2O at room temperature under solvent free conditions. The procedure gave the products in excellent yields in very short reaction times and good to high yields. Also this catalyst can be reused for several times without loss of its catalytic activity.

SnCl2.2H2O and Ni(OAc)2.4H2O: Efficient heterogeneous inorganic catalysts for the chemoselective synthesis of geminal diacetates (acylal) under solvent-free conditions

SnCl2.2H2O and Ni(OAc)2.4H2O were found to be efficient catalysts for preparation of 1,1-diacetates under solvent-free conditions at room temperature. Easy work-up and low cost are important features from the environmental and economical points of view, are distinct aspects of this research. Very good to exellent yields, short reaction times, non-toxicity and stability of the catalysts are noteworthy advantages of this method.

A new and efficient procedure for the production of 1,1-diacetate from corresponding aldehydes promoted by silica chromate (SiO2-O-CrO 2-O-SiO2)

Chemical Equation Presented A wide range of aromatic aldehydes has been selectively converted to 1,1-diacetates using silica chromate (SiO 2-O-CrO2-O-SiO2) under solvent-free conditions at room temperature in moderate to good yields. This protocol is mild and efficient compared to other reported methods. Copyright Taylor & Francis Group, LLC.

Sulphated zirconia as an eco-friendly catalyst in acylal preparation under solvent-free conditions, acylal deprotection assisted by microwaves, and the synthesis of anhydro-dimers of o-hydroxybenzaldehydes

A solvent-free approach is described for the regioselective synthesis of acylals (1,1-diacetates) in shorter reaction times and higher yields, compared to conventional methodology using solvents. In the protection reaction of the o-hydroxybenzaldehyde the formation of acetyl compounds and anhydro-dimers was observed. The deprotection reaction involves microwave (MW) exposure of diluted reactants in the presence of solid sulphated zirconia (SZ) catalyst that can be easily recovered and reused. The sulphated zirconia was recycled several times without any loss of activity.

Lithium trifluoromethanesulfonate (LiOTf) as a recyclable catalyst for highly efficient acetylation of alcohols and diacetylation of aldehydes under mild and neutral reaction conditions

A variety of alcohols and aldehydes were reacted with acetic anhydride at room temperature in the presence of a catalytic amount of lithium triflate (LiOTf) to produce the corresponding esters and 1,1-diacetates, respectively, in good to excellent yields under essentially neutral reaction conditions. Sensitive functional groups such as PhCO2-, OMe, and OTBDMS ethers survived intact under the described reaction conditions.

Pharmaceutical compositions

Pharmaceutical compositions which are useful for the treatment of cancer or illnesses which arise due to an abnormally elevated cell proliferation comprise acyl derivatives of aromatic aldehydes, especially arylidene diesters and α-alkoxyarylidene esters of general formula (I). STR1