120161-07-1Relevant articles and documents
Synthesis, SAR study, and biological evaluation of novel 2,3-dihydro-1H-imidazo[1,2-a]benzimidazole derivatives as phosphodiesterase 10A inhibitors
Chino, Ayaka,Honda, Shugo,Morita, Masataka,Yonezawa, Koichi,Hamaguchi, Wataru,Amano, Yasushi,Moriguchi, Hiroyuki,Yamazaki, Mayako,Aota, Masaki,Tomishima, Masaki,Masuda, Naoyuki
, p. 3692 - 3706 (2019/07/12)
Phosphodiesterase 10A (PDE10A) inhibitors were designed and synthesized based on the dihydro-imidazobenzimidazole scaffold. Compound 5a showed moderate inhibitory activity and good permeability, but unfavorable high P-glycoprotein (P-gp) liability for bra