1201634-40-3Relevant academic research and scientific papers
Asymmetrie synthesis of 1,1-diarylalkyl units by a copper hydride catalyzed reduction: Differentiation between two Similar aryl substituents
Yoo, Kihyun,Kim, Hyohyun,Yun, Jaesook
supporting information; experimental part, p. 11134 - 11138 (2010/04/25)
An efficient method for the preparation of enantiomerically enriched 1,1-diarylalkyl units has been developed. The use of copper hydride complexed by the (R)-1-[(5)-2-diphenylphosphino)ferrocenyl]ethyldicyclohexylphosphine (Josiphos) ligand effects a highly enantioselective conju-gate reduction of β,β-diaryl-substituted α,β-unsaturated nitriles with aryl groups of similar steric demand and no secondary coordination site. A range of substrates with meta and para substituents on the aryl group were reduced with good to excellent enantioselectivities (up to 97% enantiomeric excess (ee)) and this methodology was applied to the formal synthesis of indatraline.
