1201634-52-7Relevant articles and documents
Palladium-Catalyzed Asymmetric Benzylic Alkylation of Active Methylene Compounds with α-Naphthylbenzyl Carbonates and Pivalates
Tabuchi, Sho,Hirano, Koji,Miura, Masahiro
, p. 6973 - 6977 (2016)
A Pd/(R)-H8-BINAP-catalyzed asymmetric benzylic alkylation of active methylene compounds has been developed. The reaction proceeds without the use of an external base, and the starting racemic diarylmethyl carbonates are converted into the optically active coupling products which contain the benzylic chiral stereocenter by a dynamic kinetic asymmetric transformation (DYKAT). Additionally, with suitable carbonates bases, the same palladium catalysis allows the corresponding pivalates to be adopted in the same DYKAT process. New dynamics: A Pd/(R)-H8-BINAP-catalyzed asymmetric benzylic alkylation of active methylene compounds has been developed. The reaction proceeds without the use of an external base, and the starting racemic diarylmethyl carbonates are converted into optically active coupling products, containing a benzylic chiral stereocenter, by a dynamic kinetic asymmetric transformation.
Copper-catalyzed 1,4-addition of organoboronates to alkylidene cyanoacetates: Mechanistic insight and application to asymmetric catalysis
Takatsu, Keishi,Shintani, Ryo,Hayashi, Tamio
supporting information; experimental part, p. 5548 - 5552 (2011/07/30)
In addition: A copper/N-heterocyclic carbene(NHC)-catalyzed 1,4-addition of organoboronates to alkylidene cyanoacetates was developed, in which the catalytic cycle is proposed to consist of a transmetalation/insertion/ligand exchange. An effective asymmetric variant has also been achieved by the use of a chiral NHC ligand (see scheme). Copyright
