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120166-69-0

DIACYLGLYCEROL KINASE INHIBITOR II, also known as R-59-949, is an inhibitor of diacylglycerol kinase α (DGK-α) with an IC50 value of 300 nM in isolated platelet plasma membranes using exogenous diacylglycerol as a substrate. It plays a crucial role in modulating various cellular processes, including signal transduction and cell proliferation.
Used in Pharmaceutical Industry:
DIACYLGLYCEROL KINASE INHIBITOR II is used as a research tool for studying the role of DGK-α in various cellular processes and its potential as a therapeutic target for different diseases.
Used in Cancer Research:
DIACYLGLYCEROL KINASE INHIBITOR II is used as a research compound for determining tumor-induced inhibition with genetically modified cytotoxic T cells expressing chimeric antigen receptors (CAR). This helps in understanding the potential of CAR-T cell therapy in cancer treatment.
Used in Leukemia Research:
DIACYLGLYCEROL KINASE INHIBITOR II is used as an experimental agent to induce pAkt and PKR-like extracellular signal-regulated kinase (pErk) signals in T-cell acute lymphoblastic leukemia (T-ALL) cells. This aids in investigating the underlying mechanisms of T-ALL and exploring potential therapeutic strategies.
Used in Diabetes Research:
DIACYLGLYCEROL KINASE INHIBITOR II is used as an inhibitor to study the role of DGK-α in high K+and glucose-induced insulin secretion in MIN6 pancreatic β-cells. This helps in understanding the regulation of insulin secretion and its implications in diabetes management.
Used in Ophthalmology Research:
DIACYLGLYCEROL KINASE INHIBITOR II is used as a therapeutic agent to prevent retinal neovascularization in a mouse model of oxygen-induced retinopathy. This highlights its potential in treating retinal disorders and vascular abnormalities in the eye.

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  • 4(1H)-Quinazolinone,3-[2-[4-[bis(4-fluorophenyl)methylene]-1-piperidinyl]ethyl]-2,3-dihydro-2-thioxo-

    Cas No: 120166-69-0

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  • 120166-69-0 Structure

  • Basic information

    1. Product Name: DIACYLGLYCEROL KINASE INHIBITOR II
    2. Synonyms: DIACYLGLYCEROL KINASE INHIBITOR I (R59 949);DIACYLGLYCEROL KINASE INHIBITOR II;3-[2-(4-[BIS(4-FLUOROPHENYL)-METHYLENE)-1-PIPERIDINYL)ETHYL]-2,3-DIHYDRO-2-THIOXO-4[1H]-QUINAZOLINONE;R59949;DIACYLGLYCEROL KINASE INHIBITOR II (R 59 949);3-[2-[4-(bis(4-fluorophenyl)methylene)-1-piperidinyl]ethyl]-2,3-dihydro-2-thioxo-4(1h)-quinazolinone;R59949, 3-[2-[4-(bis(4-Fluorophenyl)methylene)-1-piperidinyl]ethyl]-2,3-dihydro-2-thioxo-4(1H)-quinazolinone;3-[2-[4-Bis(4-fluorophenyl)methylenepiperidino]ethyl]-2,3-dihydro-2-thioxoquinazolin-4(1H)-one
    3. CAS NO:120166-69-0
    4. Molecular Formula: C28H25F2N3OS
    5. Molecular Weight: 489.58
    6. EINECS: N/A
    7. Product Categories: quinazolinone
    8. Mol File: 120166-69-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 637.1 °C at 760 mmHg
    3. Flash Point: 339.1 °C
    4. Appearance: pale yellow/solid
    5. Density: 1.36 g/cm3
    6. Vapor Pressure: 3.94E-16mmHg at 25°C
    7. Refractive Index: 1.688
    8. Storage Temp.: −20°C
    9. Solubility: 0.1 M HCl: slightly soluble
    10. PKA: 11.24±0.20(Predicted)
    11. CAS DataBase Reference: DIACYLGLYCEROL KINASE INHIBITOR II(CAS DataBase Reference)
    12. NIST Chemistry Reference: DIACYLGLYCEROL KINASE INHIBITOR II(120166-69-0)
    13. EPA Substance Registry System: DIACYLGLYCEROL KINASE INHIBITOR II(120166-69-0)

  • Safety Data

    1. Hazard Codes: Xi
    2. Statements: 36/37/38
    3. Safety Statements: 26-36
    4. WGK Germany: 3
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 120166-69-0(Hazardous Substances Data)

120166-69-0 Usage

Biochem/physiol Actions

Diacylglycerol kinase inhibitor. Inhibits formation of [38P]1-Oleoyl-2-acetylglyceryl-3-phosphoric acid (OAPA) in red blood cell membranes: IC50 = 3.3 μM.

Check Digit Verification of cas no

The CAS Registry Mumber 120166-69-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,0,1,6 and 6 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 120166-69:
(8*1)+(7*2)+(6*0)+(5*1)+(4*6)+(3*6)+(2*6)+(1*9)=90
90 % 10 = 0
So 120166-69-0 is a valid CAS Registry Number.
InChI:InChI=1/C28H25F2N3OS/c29-22-9-5-19(6-10-22)26(20-7-11-23(30)12-8-20)21-13-15-32(16-14-21)17-18-33-27(34)24-3-1-2-4-25(24)31-28(33)35/h1-12H,13-18H2,(H,31,35)

120166-69-0 Well-known Company Product Price

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  • Sigma

  • (D5794)  Diacylglycerol Kinase Inhibitor II  solid

  • 120166-69-0

  • D5794-1MG

  • 499.59CNY

  • Detail

  • Sigma

  • (D5794)  Diacylglycerol Kinase Inhibitor II  solid

  • 120166-69-0

  • D5794-5MG

  • 1,432.08CNY

  • Detail

120166-69-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-[2-[4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl]ethyl]-2-sulfanylidene-1H-quinazolin-4-one

1.2 Other means of identification

Product number -
Other names Diacylglycerol Kinase Inhibitor II

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

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Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:120166-69-0 SDS

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