120167-69-3Relevant academic research and scientific papers
Method for synthesizing fluorinated pyridazinone through one-pot process
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Paragraph 0018; 0019; 0020; 0021, (2017/04/14)
The invention discloses a novel method for synthesizing fluorinated pyridazinone through a one-pot process. The method includes: adding halogenated pyridazinone with a structure shown as a formula (I) and trisubstituted tertiary amine with a structure shown as a formula (III) into a reaction container; directly feeding carbon dioxide and hydrogen fluoride gas generated by trifluoromethane through high-temperature decomposition of at temperature of 20-130 DEG C; stirring for reaction at the temperature; using thin-layer chromatography for tracking, and after reaction is finished, cooling; adding a proper amount of dichloromethane into a reaction liquid for dilution; using column chromatography for separation and purification to obtain fluorinated pyridazinone with a structure shown as a formula (II), wherein R in the formula (I) and the formula (II) and R1, R2 and R3 in the formula (III) refers to alkyl with 1-10 carbon atoms or aryl containing various substituted groups and with 6-10 carbon atoms, X refers to chlorine atoms or bromine atoms. The novel method is provided, and renewable energy sources are utilized.
Novel method for preparing fluorination reagent and its application to synthesis of fluoropyridazinones
Pei, Wen,Yang, Wei
experimental part, p. 535 - 539 (2010/04/06)
4-Chloro-5-fluoro-2-aryl-3(2H)-pyridazinones were obtained by the fluorination of 4,5-dichloro-2-aryl-3(2H)-pyridazinones with ethylhexamethylenetetramine fluoride in excellent yields. The ethylhexamethylenetetramine fluoride was synthesized by the reacti
