1201685-75-7Relevant academic research and scientific papers
Efficient formal synthesis of oseltamivir phosphate (Tamiflu) with inexpensive D-ribose as the starting material
Osato, Hiroshi,Jones, Ian L.,Chen, Anqi,Chai, Christina L. L.
supporting information; experimental part, p. 60 - 63 (2010/03/03)
Chemical Equation Presented An efficient formal synthesis of oseltamivir phosphate (Tamiflu) has been achieved in 12 steps with use of the inexpensive and highly abundant D-ribose as the starting material. This concise alternative route does not utilize protecting groups and features the introduction of 3-pentylidene ketal as the latent 3-pentyl ether, the use of a highly efficient RCM reaction to form the Tamiflu skeleton, and selective functional group manipulations.
