1201695-25-1

Basic information

• Product Name: 7-(2,3-O-isopropylidene-5-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)-4-phenyl-7H-pyrrolo[2,3-d]pyrimidine
• Synonyms: 7-(2,3-O-isopropylidene-5-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)-4-phenyl-7H-pyrrolo[2,3-d]pyrimidine
• CAS NO: 1201695-25-1
• Molecular Weight: 481.667
• Mol File: 1201695-25-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 7-(2,3-O-isopropylidene-5-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)-4-phenyl-7H-pyrrolo[2,3-d]pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 7-(2,3-O-isopropylidene-5-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)-4-phenyl-7H-pyrrolo[2,3-d]pyrimidine(1201695-25-1)
• EPA Substance Registry System: 7-(2,3-O-isopropylidene-5-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)-4-phenyl-7H-pyrrolo[2,3-d]pyrimidine(1201695-25-1)

Safety Data

• Hazardous Substances Data: 1201695-25-1(Hazardous Substances Data)

Upstream product

• 115479-39-5 4-chloro-7-<5-O-<(1,1-dimethylethyl)dimethylsilyl>-2,3-O-(1-methylethylidene)-β-D-ribofuranosyl>-7H-pyrrolo<2,3-d>pyrimidine 
• 98-80-6 phenylboronic acid 

Downstream Products

• 144928-12-1 4-phenyl-7-(β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine 

Relevant articles and documents

6-(Het)aryl-7-deazapurine ribonucleosides as novel potent cytostatic agents

A series of novel 7-deazapurine ribonucleosides bearing an alkyl, aryl, or hetaryl group in position 6 and H, F, or Cl atom in position 7 has been prepared either by Pd-catalyzed cross-coupling reactions of the corresponding protected 6-chloro-(7-halogenated-)7-deazapurine ribonucleosides with alkyl- or (het)-arylorganometallics followed by deprotection, or by single-step aqueous phase cross-coupling reactions of unprotected 6-chloro-(7-halogenated-)7- deazapurine ribonucleosides with (het)arylboronic acids. Significant cytostatic effect was detected with a substantial proportion of the prepared compounds. The most potent were 7-H or 7-F derivatives of 6-furyl- or 6-thienyl-7-deazapurines displaying cytostatic activity in multiple cancer cell lines with a geometric mean of 50% growth inhibition concentration ranging from 16 to 96 nM, a potency comparable to or better than that of the nucleoside analogue clofarabine. Intracellular phosphorylation to mono- and triphosphates and the inhibition of total RNA synthesis was demonstrated in preliminary study of metabolism and mechanism of action studies. 2009 American Chemical Society.